Evidence map›Paper›PMID 34949129›Full record

Trial reportNeurorehabilitation and neural repair2022

Step Number and Aerobic Minute Exercise Prescription and Progression in Stroke: A Roadmap.

Sue Peters, Tara Klassen, Amy Schneeberg, Sean Dukelow, Mark Bayley, Michael Hill, Sepideh Pooyania, Jennifer Yao, Janice Eng

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurorehabilitation and neural repair, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01915368 (Determining Optimal Post-Stroke Exercise), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01915368 nacompletednot on this map

Determining Optimal Post-Stroke Exercise (DOSE)

TypeinterventionalSponsorUniversity of British ColumbiaRan2013 to 2019Enrolled75ConditionsCerebrovascular Accident, Stroke, Cerebral Infarction, Brain InfarctionArmsStroke Management Program (SMP), Stroke Monitoring Program (SMonP), Stroke Supplementary Program (SSP)
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. High-Intensity Gait Training for Patients After Stroke: A Feasibility Study.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sue PetersSchool of Physical Therapy, 6221University of Western Ontario, Ontario, Canada.
Tara KlassenDepartment of Physical Therapy, University of British Columbia, Vancouver, Canada.
Amy SchneebergDepartment of Physical Therapy, University of British Columbia, Vancouver, Canada.
Sean DukelowDepartment of Clinical Neurosciences and Hotchkiss Brain Institute, 2129University of Calgary, Calgary, Canada.
Mark BayleyBrain and Spinal Cord Rehab program, Toronto Rehabilitation Institute - University Health Network, Toronto, Canada.
Michael HillDepartment of Clinical Neurosciences and Hotchkiss Brain Institute, 2129University of Calgary, Calgary, Canada.
Sepideh PooyaniaDivision of Physical Medicine and Rehabilitation, 8664University of Manitoba, Winnipeg, USA.ORCID 0000-0002-7906-9953
Jennifer YaoVancouver Coastal Health, 103221G F Strong Rehabilitation Hospital, Vancouver, Canada.
Janice EngDepartment of Physical Therapy, University of British Columbia, Vancouver, Canada.ORCID 0000-0002-2093-0788

Funding

CIHR FDN 143340
6 · The paper itself

Abstract

backgroundWhile higher therapeutic intensity improves motor recovery after stroke, translating findings from successful studies is challenging without clear exercise intensity targets. We show in the DOSE trial

objectiveWe modeled data from this successful higher intensity multi-site RCT to develop targets for prescribing and progressing exercise for varying levels of walking impairment after stroke.

methodsIn twenty-five individuals in inpatient rehabilitation, twenty sessions were monitored for a total of 500 one-hour physical therapy sessions. For the 500 sessions, step number and aerobic minute progression were modeled using linear mixed effects regression. Using formulas from the linear mixed effects regression, targets were calculated.

resultsThe model for step number included session number and baseline walking speed, and for aerobic minutes, session number and age. For steps, there was an increase of 73 steps per session. With baseline walking speed, for every 0.1 m/s increase, a corresponding increase of 302 steps was predicted. For aerobic minutes, there was an increase of .56 minutes of aerobic activity (ie, 34 seconds) per session. For every year increase in age, a decrease of .39 minutes (ie, 23 seconds) was predicted.

conclusionsUsing data associated with better walking outcomes, we provide step number and aerobic minute targets that future studies can cross-validate. As walking speed and age are collected at admission, these models allow for uptake of routine measurement of therapeutic intensity.Registration: www.clinicaltrials.gov; NCT01915368.

Indexed as

Clinical ProtocolsExercise TherapyStroke RehabilitationAdultAgedFemaleGait Disorders, NeurologicHumansMaleMiddle AgedOutcome and Process Assessment, Health CareStrokeexercisegaitoutcomesRehabilitationstroke

Identifiers

PMID34949129
PMCPMC8796151

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.