Evidence map›Paper›PMID 34948786›Full record

ArticleInternational journal of environmental research and public health2021

Decreased Levels of Soluble CD44 in a High-Risk Population following a Smoking Cessation Program.

Drew H Smith, Shahm Raslan, Isildinha M Reis, Abdurrahman Al-Awady, Isabella Buitron, Melanie Perez, Huaping Liu, Jerri Halgowich, Claudia Gordon, Monica Webb Hooper and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Drew H SmithDepartment of Otolaryngology-Head and Neck Surgery, University of Miami Leonard Miller School of Medicine, Miami, FL 33136, USA.ORCID 0000-0001-9671-542X
Shahm RaslanDepartment of Otolaryngology-Head and Neck Surgery, University of Miami Leonard Miller School of Medicine, Miami, FL 33136, USA.
Isildinha M ReisSylvester Comprehensive Cancer Center, University of Miami Leonard Miller School of Medicine, Miami, FL 33136, USA.
Abdurrahman Al-AwadyDepartment of Otolaryngology-Head and Neck Surgery, University of Miami Leonard Miller School of Medicine, Miami, FL 33136, USA.
Isabella BuitronDepartment of Otolaryngology-Head and Neck Surgery, University of Miami Leonard Miller School of Medicine, Miami, FL 33136, USA.ORCID 0000-0002-0897-0429
Melanie PerezDepartment of Otolaryngology-Head and Neck Surgery, University of Miami Leonard Miller School of Medicine, Miami, FL 33136, USA.ORCID 0000-0001-6251-8487
Huaping LiuDepartment of Otolaryngology-Head and Neck Surgery, University of Miami Leonard Miller School of Medicine, Miami, FL 33136, USA.
Jerri HalgowichDepartment of Otolaryngology-Head and Neck Surgery, University of Miami Leonard Miller School of Medicine, Miami, FL 33136, USA.
Claudia GordonSylvester Comprehensive Cancer Center, University of Miami Leonard Miller School of Medicine, Miami, FL 33136, USA.
Monica Webb HooperCase Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44016, USA.
Noël C BarengoDepartment of Translational Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA.ORCID 0000-0003-0660-3091
Elizabeth J FranzmannDepartment of Otolaryngology-Head and Neck Surgery, University of Miami Leonard Miller School of Medicine, Miami, FL 33136, USA.
University of Miami · USCase Western Reserve University · USFlorida International University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tobacco is a risk factor of head and neck cancer (HNC) and smoking cessation alone may reduce HNC risk by 70%. Soluble CD44 (solCD44), a cell surface receptor linked to cell proliferation and migration, and total protein (TP) levels can detect early HNC. This study aims to determine whether salivary solCD44 and TP levels in oral rinses change following a smoking cessation program. 150 smokers provided oral rinse samples at baseline and at a 12-month follow-up after participation in a smoking cessation program. Assays to measure levels of solCD44, TP, and cotinine, a metabolite used as a biomarker of tobacco exposure, were completed. A paired-samples t-test was used to determine whether there was a statistically significant (

Indexed as

Head and Neck NeoplasmsSmoking CessationCotinineHumansHyaluronan ReceptorsRisk FactorsSmokingCD44 protein, humanCotinineHyaluronan Receptorscotininehead and neck cancersmoking interventionsolCD44tobaccototal protein

Identifiers

PMID34948786
PMCPMC8700947
OpenAlexW4200615776

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.