Evidence map›Paper›PMID 34948446›Full record

ReviewInternational journal of molecular sciences2021

Role of Circulating Biomarkers in Platinum-Resistant Ovarian Cancer.

Carolina Maria Sassu, Innocenza Palaia, Serena Maria Boccia, Giuseppe Caruso, Giorgia Perniola, Federica Tomao, Violante Di Donato, Angela Musella, Ludovico Muzii

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Multi-omics characterization of Yao syndrome identifies three pathophysiological axes and disease-specific divergence from Blau syndrome.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
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  6. Review
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Carolina Maria SassuDepartment of Maternal and Child Health and Urological Sciences, "Sapienza" University of Rome, Polyclinic Umberto I, 00161 Rome, Italy.
Innocenza PalaiaDepartment of Maternal and Child Health and Urological Sciences, "Sapienza" University of Rome, Polyclinic Umberto I, 00161 Rome, Italy.
Serena Maria BocciaDepartment of Maternal and Child Health and Urological Sciences, "Sapienza" University of Rome, Polyclinic Umberto I, 00161 Rome, Italy.
Giuseppe CarusoDepartment of Maternal and Child Health and Urological Sciences, "Sapienza" University of Rome, Polyclinic Umberto I, 00161 Rome, Italy.ORCID 0000-0001-5501-1936
Giorgia PerniolaDepartment of Maternal and Child Health and Urological Sciences, "Sapienza" University of Rome, Polyclinic Umberto I, 00161 Rome, Italy.
Federica TomaoDepartment of Maternal and Child Health and Urological Sciences, "Sapienza" University of Rome, Polyclinic Umberto I, 00161 Rome, Italy.
Violante Di DonatoDepartment of Maternal and Child Health and Urological Sciences, "Sapienza" University of Rome, Polyclinic Umberto I, 00161 Rome, Italy.ORCID 0000-0002-9254-5790
Angela MusellaDepartment of Maternal and Child Health and Urological Sciences, "Sapienza" University of Rome, Polyclinic Umberto I, 00161 Rome, Italy.
Ludovico MuziiDepartment of Maternal and Child Health and Urological Sciences, "Sapienza" University of Rome, Polyclinic Umberto I, 00161 Rome, Italy.ORCID 0000-0001-7195-9583

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian cancer (OC) is the second most common cause of death in women with gynecological cancer. Considering the poor prognosis, particularly in the case of platinum-resistant (PtR) disease, a huge effort was made to define new biomarkers able to help physicians in approaching and treating these challenging patients. Currently, most data can be obtained from tumor biopsy samples, but this is not always available and implies a surgical procedure. On the other hand, circulating biomarkers are detected with non-invasive methods, although this might require expensive techniques. Given the fervent hope in their value, here we focused on the most studied circulating biomarkers that could play a role in PtR OC.

Indexed as

Drug Resistance, NeoplasmBiomarkers, TumorFemaleHumansOvarian NeoplasmsPlatinumPrognosisBiomarkers, TumorPlatinumcirculating biomarkerdrug response biomarkerliquid biopsyplatinum-resistant ovarian cancerprognosis

Identifiers

PMID34948446
PMCPMC8707281

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.