Evidence map›Paper›PMID 34948352›Full record

ArticleInternational journal of molecular sciences2021

Tobramycin Supplemented Small-Diameter Vascular Grafts for Local Antibiotic Delivery: A Preliminary Formulation Study.

Mariella Rosalia, Priusha Ravipati, Pietro Grisoli, Rossella Dorati, Ida Genta, Enrica Chiesa, Giovanna Bruni, Bice Conti

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Tobramycin Nanoantibiotics and Their Advantages: A Minireview.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Mariella RosaliaDepartment of Drug Sciences, Pharmaceutical Section, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy.
Priusha RavipatiDepartment of Drug Sciences, Pharmaceutical Section, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy.
Pietro GrisoliDepartment of Drug Sciences, Pharmacological Section, University of Pavia, Via Taramelli 16, 27100 Pavia, Italy.ORCID 0000-0003-2016-0135
Rossella DoratiDepartment of Drug Sciences, Pharmaceutical Section, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy.ORCID 0000-0001-5774-9547
Ida GentaDepartment of Drug Sciences, Pharmaceutical Section, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy.ORCID 0000-0001-5710-0588
Enrica ChiesaDepartment of Surgery, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.
Giovanna BruniConsorzio per lo Sviluppo dei Sistemi a Grande Interfase (C.S.G.I.) & Department of Chemistry, Physical Chemistry Section, University of Pavia, Via Taramelli 10, 27100 Pavia, Italy.ORCID 0000-0003-1958-2998
Bice ContiDepartment of Drug Sciences, Pharmaceutical Section, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy.ORCID 0000-0002-0034-2815
University of Pavia · ITPoliclinico San Matteo Fondazione · IT

Funding

NANOMED EMJMD 574439-EPP-1-FR-EPPKA1-JMD-MOB
6 · The paper itself

Abstract

Peripheral artery occlusive disease is an emerging cardiovascular disease characterized by the blockage of blood vessels in the limbs and is associated with dysfunction, gangrene, amputation, and a high mortality risk. Possible treatments involve by-pass surgery using autologous vessel grafts, because of the lack of suitable synthetic small-diameter vascular prosthesis. One to five percent of patients experience vascular graft infection, with a high risk of haemorrhage, spreading of the infection, amputation and even death. In this work, an infection-proof vascular graft prototype was designed and manufactured by electrospinning 12.5%

Indexed as

Blood Vessel ProsthesisDrug Delivery SystemsAnti-Bacterial AgentsDrug CarriersDrug LiberationEscherichia coliEscherichia coli InfectionsHumansPolylactic Acid-Polyglycolic Acid CopolymerStaphylococcal InfectionsStaphylococcus aureusTobramycinVascular GraftingAnti-Bacterial AgentsDrug CarriersPolylactic Acid-Polyglycolic Acid CopolymerTobramycinelectrospinninglocal drug deliverymicrobicidal effectsmall-diameter vascular grafttobramycin

Identifiers

PMID34948352
PMCPMC8709041
OpenAlexW4200485441

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.