ReviewInternational journal of molecular sciences2021
The Role of the Inflammatory Response in Mediating Functional Recovery Following Composite Tissue Injuries.
Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Pathophysiology-guided biomarkers and therapeutics for precision trauma medicine in polytrauma with musculoskeletal injuries.Military Medical Research · 2026Review
- Inflammasome-derived biomarkers in wound healing: linking tissue repair, chronic inflammation, fibrosis, and precision therapeutics.Molecular biology reports · 2026Review
- From Exposure to Outcome: Air Pollution-Induced Oxidative Stress as a Determinant of Early and Late Outcomes After Coronary Artery Bypass Grafting.Antioxidants (Basel, Switzerland) · 2026Review
- Efficacy of high-dose serrapeptase (serratiopeptidase) in inflammation among orthopedic trauma patients.Journal of medicine and life · 2026Observational
- Multifunctional Hydrogel-Based Scaffolds: Integrating Conductive Nanomaterials for Smart Wound Healing Applications.Gels (Basel, Switzerland) · 2026Review
- Novel AI-Driven Precision Strategies in Diabetic Wound Healing: Immunomodulation and Advances in Smart Composite Nanocarriers.Pharmaceutics · 2026Review
- The Osteoimmunologic Basis of Biologic and Bioengineered Scaffolds in Fracture Healing.Bioengineering (Basel, Switzerland) · 2026Review
- Enhanced Facial Rejuvenation: Biostimulatory Effects of Hylan Gel Dermal Filler DX on Collagen Synthesis and Tissue Regeneration.Aesthetic plastic surgery · 2026Article
- The Effectiveness of Cerium Oxide Nanoparticle-Based Drugs in Wound Healing in Animal Models.Molecules (Basel, Switzerland) · 2025Review
- The Role of Inflammatory Biomarkers in Predicting Postoperative Fever Following Flexible Ureteroscopy.Medicina (Kaunas, Lithuania) · 2025Article
- Applications of Growth Factors in Implant Dentistry.Current issues in molecular biology · 2025Review
- Inflammatory markers CRP and WBC as predictors of liver function impairment in multiple injury trauma patients: a repeated measures analysis.Frontiers in medicine · 2025Article
- Inflammatory Cell Interactions in the Rotator Cuff Microenvironment: Insights From Single-Cell Sequencing.International journal of genomics · 2025Review
- Unveiling cytokine charge disparity as a potential mechanism for immune regulation.Cytokine & growth factor reviews · 2024Review
- The influence of microbial colonization on inflammatory versus pro-healing trajectories in combat extremity wounds.Scientific reports · 2024Article
- Recent advances in molecular mechanisms of skin wound healing and its treatments.Frontiers in immunology · 2024Review
- Donor Age, Sex, and Cause of Death and Their Relationship to Heart Transplant Recipient Cardiac Death.Journal of clinical medicine · 2023Article
- Article
- Effectiveness of Two Stress Reduction Interventions in Patients with Chronic Diabetic Foot Ulcers (PSY-DFU): Protocol for a Longitudinal RCT with a Nested Qualitative Study Involving Family Caregivers.International journal of environmental research and public health · 2022Article
- Translational and Clinical Significance of DAMPs, PAMPs, and PRRs in Trauma-induced Inflammation.Archives of clinical and biomedical research · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Composite tissue injuries (CTI) are common among US Military Service members during combat operations, and carry a high potential of morbidity. Furthermore, CTI are often complicated due to an altered wound healing response, resulting in part from a dysregulation of the innate and adaptive immune responses. Unlike normal wound healing, in CTI, disruptions occur in innate immune responses, altering neutrophil functions, macrophage activation and polarization, further impacting the functions of T regulatory cells. Additionally, the biological underpinnings of these unfavorable wound healing conditions are multifactorial, including various processes, such as: ischemia, hypoxia, low nutrient levels, and altered cell metabolic pathways, among others, all of which are thought to trigger anergy in immune cells and destabilize adaptive immune responses. As a result, impaired wound healing is common in CTI. Herein, we review the altered innate and adaptive immune cells and their metabolic status and responses following CTI, and discuss the role a multi-pronged immunomodulatory approach may play in facilitating improved outcomes for afflicted patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.