Evidence map›Paper›PMID 34948326›Full record

ReviewInternational journal of molecular sciences2021

Cell Fate Decisions in the Neural Crest, from Pigment Cell to Neural Development.

Jonathan H P Dawes, Robert N Kelsh

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

  1. A zebrafish module for genetic problem-solving.Journal of microbiology & biology education · 2026
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  12. Glia Development and Function in the NematodeCold Spring Harbor perspectives in biology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jonathan H P DawesCentre for Networks and Collective Behaviour, University of Bath, Bath BA2 7AY, UK.ORCID 0000-0002-4347-9985
Robert N KelshCentre for Mathematical Biology, University of Bath, Bath BA2 7AY, UK.ORCID 0000-0002-9381-0066
University of Bath · GB

Funding

Biotechnology and Biological Sciences Research Council BB/S015906/1
6 · The paper itself

Abstract

The neural crest shows an astonishing multipotency, generating multiple neural derivatives, but also pigment cells, skeletogenic and other cell types. The question of how this process is controlled has been the subject of an ongoing debate for more than 35 years. Based upon new observations of zebrafish pigment cell development, we have recently proposed a novel, dynamic model that we believe goes some way to resolving the controversy. Here, we will firstly summarize the traditional models and the conflicts between them, before outlining our novel model. We will also examine our recent dynamic modelling studies, looking at how these reveal behaviors compatible with the biology proposed. We will then outline some of the implications of our model, looking at how it might modify our views of the processes of fate specification, differentiation, and commitment.

Indexed as

AnimalsCell DifferentiationGene Expression Regulation, DevelopmentalNeural CrestNeurogenesisZebrafishcommitmentdifferentiationdorsal root ganglionfate specificationglianeural crest cellsperipheral nervous systemSchwann cellsensory neuronsympathetic neuron

Identifiers

PMID34948326
PMCPMC8706606
OpenAlexW4200082996

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.