Evidence map›Paper›PMID 34948255›Full record

ArticleInternational journal of molecular sciences2021

Conditioned Medium from Bone Marrow Mesenchymal Stem Cells Restored Oxidative Stress-Related Impaired Osteogenic Differentiation.

Ragda Saleem, Samih Mohamed-Ahmed, Rammah Elnour, Ellen Berggreen, Kamal Mustafa, Niyaz Al-Sharabi

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 27 citations in OpenAlex.

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  19. MSC-ACE2 AmelioratesFrontiers in immunology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ragda SaleemCenter of Translational Oral Research (TOR)-Tissue Engineering Group, Department of Clinical Dentistry, Faculty of Medicine, University of Bergen, 5009 Bergen, Norway.
Samih Mohamed-AhmedCenter of Translational Oral Research (TOR)-Tissue Engineering Group, Department of Clinical Dentistry, Faculty of Medicine, University of Bergen, 5009 Bergen, Norway.
Rammah ElnourDepartment of Clinical Medicine, Faculty of Medicine, University of Bergen, 5009 Bergen, Norway.
Ellen BerggreenOral Health Centre of Expertise in Western Norway, 5009 Bergen, Norway.
Kamal MustafaCenter of Translational Oral Research (TOR)-Tissue Engineering Group, Department of Clinical Dentistry, Faculty of Medicine, University of Bergen, 5009 Bergen, Norway.
Niyaz Al-SharabiCenter of Translational Oral Research (TOR)-Tissue Engineering Group, Department of Clinical Dentistry, Faculty of Medicine, University of Bergen, 5009 Bergen, Norway.
University of Bergen · NO

Funding

Trond Mohn Foundation BFS2018TMT10
6 · The paper itself

Abstract

Oxidative stress from high levels of intracellular reactive oxygen species (ROS) has been linked to various bone diseases. Previous studies indicate that mesenchymal stem cells (MSC) secrete bioactive factors (conditioned medium (MSC-CM)) that have antioxidant effects. However, the antioxidant role of MSC-CM on osteogenesis has not been fully studied. We aimed to identify antioxidant proteins in MSC-CM using mass spectrometry-based proteomics and to explore their effects on osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSC) exposed to oxidative stress induced by hydrogen peroxide (H

Indexed as

AntioxidantsApoptosisBone Marrow CellsCell DifferentiationCell ProliferationCells, CulturedCulture Media, ConditionedHumansMesenchymal Stem CellsOsteogenesisOxidative StressReactive Oxygen SpeciesAntioxidantsCulture Media, ConditionedReactive Oxygen Speciesantioxidantconditioned mediummesenchymal stem cellsosteogenic differentiationoxidative stress

Identifiers

PMID34948255
PMCPMC8706339
OpenAlexW4200385263

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.