Evidence map›Paper›PMID 34948216›Full record

ArticleInternational journal of molecular sciences2021

Identification of African Swine Fever Virus Inhibitors through High Performance Virtual Screening Using Machine Learning.

Jiwon Choi, Dongseob Tark, Yun-Sook Lim, Soon B Hwang

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Jiwon ChoiCollege of Pharmacy, Dongduk Women's University, Seoul 02748, Korea.ORCID 0000-0002-0786-6187
Dongseob TarkLaboratory for Infectious Disease Prevention, Korea Zoonosis Research Institute, Jeonbuk National University, Iksan 54596, Korea.
Yun-Sook LimLaboratory of RNA Viral Diseases, Korea Zoonosis Research Institute, Jeonbuk National University, Iksan 54596, Korea.
Soon B HwangLaboratory of RNA Viral Diseases, Korea Zoonosis Research Institute, Jeonbuk National University, Iksan 54596, Korea.
Jeonbuk National University · KRDongduk Women's University · KRHallym University · KR

Funding

Ministry of Agriculture, Food and Rural Affairs (MAFRA) grant no. 3200532 to D.T.National Research Foundation of Korea NRF-2018R1D1A1B07050744National Research Foundation of Korea NRF-2019R1A2C1086914
6 · The paper itself

Abstract

African swine fever virus (ASFV) is a highly contagious virus that causes severe hemorrhagic viral disease resulting in high mortality in domestic and wild pigs, until few antiviral agents can inhibit ASFV infections. Thus, new anti-ASFV drugs need to be urgently identified. Recently, we identified pentagastrin as a potential antiviral drug against ASFVs using molecular docking and machine learning models. However, the scoring functions are easily influenced by properties of protein pockets, resulting in a scoring bias. Here, we employed the 5'-P binding pocket of

Indexed as

African Swine FeverAfrican Swine Fever VirusAnimalsAntiviral AgentsBinding SitesMachine LearningSwineViral ProteinsVirus ReplicationAntiviral AgentsViral ProteinsAfrican swine fever virusAsfvPolXcangrelorfostamatinibmachine learningmolecular docking

Identifiers

PMID34948216
PMCPMC8703626
OpenAlexW4200479221

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.