Evidence map›Paper›PMID 34948128›Full record

ArticleInternational journal of molecular sciences2021

Enhanced p53 Levels Are Involved in the Reduced Mineralization Capacity of Osteoblasts Derived from Shwachman-Diamond Syndrome Subjects.

Annalisa Frattini, Simona Bolamperti, Roberto Valli, Marco Cipolli, Rita Maria Pinto, Elena Bergami, Maria Rita Frau, Simone Cesaro, Michela Signo, Valentino Bezzerri and 4 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

Annalisa FrattiniInstitute for Genetic and Biomedical Research (IRGB), UOS Milano CNR, Via Fantoli, 15/16, 20138 Milano, Italy.ORCID 0000-0002-1166-3091
Simona BolampertiBone Metabolism Unit, IRCCS Ospedale San Raffaele, Via Olgettina, 60, 20132 Milano, Italy.ORCID 0000-0002-8940-8859
Roberto ValliDepartment of Medicine and Surgery (DMC), Universita' degli Studi dell'Insubria, Via J.H. Dunant, 5, 21100 Varese, Italy.ORCID 0000-0002-3209-8917
Marco CipolliCystic Fibrosis Center, Azienda Ospedaliera Universitaria Integrata di Verona, Piazzale Aristide Stefani, 1, 37126 Verona, Italy.
Rita Maria PintoDepartment of Onco-Hematology, Ospedale Bambino Gesù IRCCS, Piazza S.Onofrio, 4, 00165 Roma, Italy.
Elena BergamiPediatric Onco-Hematology, IRCCS Policlinico San Matteo, Viale Camillo Golgi, 19, 27100 Pavia, Italy.
Maria Rita FrauPediatrics and Intensive Neonatal Therapy, Ospedale San Francesco, Via Salvatore Mannironi, 08100 Nuoro, Italy.
Simone CesaroPediatric Hematology Oncology, Ospedale Donna Bambino, Azienda Ospedaliera Universitaria Integrata, Piazzale Aristide Stefani, 1, 37126 Verona, Italy.ORCID 0000-0002-8698-9547
Michela SignoBone Metabolism Unit, IRCCS Ospedale San Raffaele, Via Olgettina, 60, 20132 Milano, Italy.
Valentino BezzerriCystic Fibrosis Center, Azienda Ospedaliero Universitaria Ospedali Riuniti di Ancona, Via Conca, 71, 60126 Ancona, Italy.ORCID 0000-0002-6849-4487
Giovanni PortaDepartment of Medicine and Surgery (DMC), Universita' degli Studi dell'Insubria, Via J.H. Dunant, 5, 21100 Varese, Italy.
Abdul Waheed KhanDepartment of Medicine and Surgery (DMC), Universita' degli Studi dell'Insubria, Via J.H. Dunant, 5, 21100 Varese, Italy.
Alessandro RubinacciBone Metabolism Unit, IRCCS Ospedale San Raffaele, Via Olgettina, 60, 20132 Milano, Italy.ORCID 0000-0003-1736-0531
Isabella VillaBone Metabolism Unit, IRCCS Ospedale San Raffaele, Via Olgettina, 60, 20132 Milano, Italy.ORCID 0000-0002-3732-4725
IRCCS Ospedale San Raffaele · ITUniversity of Insubria · ITAzienda Ospedaliera Universitaria Integrata Verona · ITBambino Gesù Children's Hospital · ITOspedali Riuniti di Ancona · ITPoliclinico San Matteo Fondazione · ITSan Salvatore Hospital · IT

Funding

AISS Grant 2018Ministero della Salute GR-2016-02363570
6 · The paper itself

Abstract

Shwachman-Diamond syndrome (SDS) is a rare autosomal recessive disorder characterized by bone marrow failure, exocrine pancreatic insufficiency, and skeletal abnormalities, caused by loss-of-function mutations in the

Indexed as

Calcification, PhysiologicCells, CulturedFemaleHumansMaleOsteoblastsProteinsShwachman-Diamond SyndromeTumor Suppressor Protein p53ProteinsSBDS protein, humanTP53 protein, humanTumor Suppressor Protein p53bone cellsmineralizationp53ribosomopathiestranscriptome

Identifiers

PMID34948128
PMCPMC8707819
OpenAlexW4200075777

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.