Evidence map›Paper›PMID 34948079›Full record

ArticleInternational journal of molecular sciences2021

New Circulating Circular RNAs with Diagnostic and Prognostic Potential in Advanced Colorectal Cancer.

Maria Radanova, Galya Mihaylova, Oskan Tasinov, Desislava P Ivanova, George St Stoyanov, Neshe Nazifova-Tasinova, Rostislav Manev, Ayshe Salim, Miglena Nikolova, Diana G Ivanova and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Maria RadanovaDepartment of Biochemistry, Molecular Medicine and Nutrigenomics, Medical University of Varna, 9000 Varna, Bulgaria.ORCID 0000-0002-0941-6139
Galya MihaylovaDepartment of Biochemistry, Molecular Medicine and Nutrigenomics, Medical University of Varna, 9000 Varna, Bulgaria.
Oskan TasinovDepartment of Biochemistry, Molecular Medicine and Nutrigenomics, Medical University of Varna, 9000 Varna, Bulgaria.ORCID 0000-0001-7268-3937
Desislava P IvanovaDepartment of Biochemistry, Molecular Medicine and Nutrigenomics, Medical University of Varna, 9000 Varna, Bulgaria.
George St StoyanovClinic of General and Clinical Pathology, University Hospital "St. Marina", 9000 Varna, Bulgaria.
Neshe Nazifova-TasinovaDepartment of Biochemistry, Molecular Medicine and Nutrigenomics, Medical University of Varna, 9000 Varna, Bulgaria.
Rostislav ManevDepartment of Oncology, Medical University of Varna, 9000 Varna, Bulgaria.
Ayshe SalimDepartment of Biochemistry, Molecular Medicine and Nutrigenomics, Medical University of Varna, 9000 Varna, Bulgaria.ORCID 0000-0002-1422-7121
Miglena NikolovaDepartment of Biochemistry, Molecular Medicine and Nutrigenomics, Medical University of Varna, 9000 Varna, Bulgaria.
Diana G IvanovaDepartment of Biochemistry, Molecular Medicine and Nutrigenomics, Medical University of Varna, 9000 Varna, Bulgaria.ORCID 0000-0002-4502-081X
Nikolay ConevDepartment of Oncology, Medical University of Varna, 9000 Varna, Bulgaria.
Zhasmina MihaylovaClinic of Medical Oncology, Military Medical Academy, 1000 Sofia, Bulgaria.
Ivan DonevClinic of Medical Oncology, Hospital "Nadezhda", 1000 Sofia, Bulgaria.
Medical University of Varna · BGMedical University of Sofia · BGMilitary Medical Academy · BG

Funding

Bulgarian Science Fund КП-06-Н23/6, 18.12.2018
6 · The paper itself

Abstract

Circular RNAs (circRNAs) are a group of special endogenous long non-coding RNAs which are highly stable in the circulation, and, thus, more suitable as new biomarkers of colorectal cancer (CRC). The aim of our study was to explore the plasma expression levels of four circRNAs: has_circ_0001445, hsa_circ_0003028, hsa_circ_0007915 and hsa_circ_0008717 in patients with CRC and to evaluate their associations with clinicopathological characteristics and the clinical outcome of the patients. CircRNAs were extracted from patients' plasma obtained prior to chemotherapy. Their expression levels were measured by qPCR and calculated applying the 2

Indexed as

AgedBiomarkers, TumorColorectal NeoplasmsFemaleHumansMaleMiddle AgedPrognosisRNA, CircularSensitivity and SpecificityTreatment OutcomeBiomarkers, TumorRNA, CircularcircABCB10circFUT8circIPO11circSMARcA5circular RNAscolorectal cancer

Identifiers

PMID34948079
PMCPMC8706615
OpenAlexW4200344835

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.