Evidence map›Paper›PMID 34948059›Full record

ReviewInternational journal of molecular sciences2021

Antifungal Peptides and Proteins to Control Toxigenic Fungi and Mycotoxin Biosynthesis.

Pedro V Martínez-Culebras, Mónica Gandía, Sandra Garrigues, Jose F Marcos, Paloma Manzanares

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
6.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 57 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Antifungal peptides from living organisms.Frontiers in microbiology · 2024
    Review
  9. Article
  10. Various Biomimetics, Including Peptides as Antifungals.Biomimetics (Basel, Switzerland) · 2023
    Review
  11. Identification and Characterization of an Antifungal GeneInternational journal of molecular sciences · 2023
    Article
  12. Protective Barriers Provided by the Epidermis.International journal of molecular sciences · 2023
    Review
  13. Genetic Regulation of Mycotoxin Biosynthesis.Journal of fungi (Basel, Switzerland) · 2022
    Review
  14. Review
  15. Article
  16. Article
  17. Modulation of extracellularFrontiers in microbiology · 2022
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Pedro V Martínez-CulebrasDepartamento de Medicina Preventiva y Salud Pública, Ciencias de la Alimentación, Bromatología, Toxicología y Medicina Legal, Universitat de València, Vicente Andrès Estellès s/n, Burjassot, 46100 Valencia, Spain.
Mónica GandíaDepartamento de Medicina Preventiva y Salud Pública, Ciencias de la Alimentación, Bromatología, Toxicología y Medicina Legal, Universitat de València, Vicente Andrès Estellès s/n, Burjassot, 46100 Valencia, Spain.ORCID 0000-0002-8663-0403
Sandra GarriguesDepartamento de Biotecnología de Alimentos, Instituto de Agroquímica y Tecnología de los Alimentos (IATA), Consejo Superior de Investigaciones Científicas (CSIC), Catedrático Agustín Escardino 7, Paterna, 46980 Valencia, Spain.ORCID 0000-0002-4104-6246
Jose F MarcosDepartamento de Biotecnología de Alimentos, Instituto de Agroquímica y Tecnología de los Alimentos (IATA), Consejo Superior de Investigaciones Científicas (CSIC), Catedrático Agustín Escardino 7, Paterna, 46980 Valencia, Spain.ORCID 0000-0003-3339-2584
Paloma ManzanaresDepartamento de Biotecnología de Alimentos, Instituto de Agroquímica y Tecnología de los Alimentos (IATA), Consejo Superior de Investigaciones Científicas (CSIC), Catedrático Agustín Escardino 7, Paterna, 46980 Valencia, Spain.ORCID 0000-0001-5036-9787
Consejo Superior de Investigaciones Científicas · ES

Funding

Conselleria d'Educació' (Generalitat Valenciana, Comunitat Valenciana, Spain) PROMETEO/2018/066Spanish Ministerio de Ciencia, Innovación y Universidades RTI2018-101115B-C21
6 · The paper itself

Abstract

The global challenge to prevent fungal spoilage and mycotoxin contamination on food and feed requires the development of new antifungal strategies. Antimicrobial peptides and proteins (AMPs) with antifungal activity are gaining much interest as natural antifungal compounds due to their properties such as structure diversity and function, antifungal spectrum, mechanism of action, high stability and the availability of biotechnological production methods. Given their multistep mode of action, the development of fungal resistance to AMPs is presumed to be slow or delayed compared to conventional fungicides. Interestingly, AMPs also accomplish important biological functions other than antifungal activity, including anti-mycotoxin biosynthesis activity, which opens novel aspects for their future use in agriculture and food industry to fight mycotoxin contamination. AMPs can reach intracellular targets and exert their activity by mechanisms other than membrane permeabilization. The mechanisms through which AMPs affect mycotoxin production are varied and complex, ranging from oxidative stress to specific inhibition of enzymatic components of mycotoxin biosynthetic pathways. This review presents natural and synthetic antifungal AMPs from different origins which are effective against mycotoxin-producing fungi, and aims at summarizing current knowledge concerning their additional effects on mycotoxin biosynthesis. Antifungal AMPs properties and mechanisms of action are also discussed.

Indexed as

Antifungal AgentsAntimicrobial PeptidesBiological ProductsFood MicrobiologyFood PreservationFungiMycotoxinsOxidative StressAntifungal AgentsAntimicrobial PeptidesBiological ProductsMycotoxinsantifungal AMPantimicrobial peptide (AMP)food preservationmechanism of actionmycotoxigenic fungimycotoxin biosynthesis

Identifiers

PMID34948059
PMCPMC8703302
OpenAlexW4200118005

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.