Evidence map›Paper›PMID 34948016›Full record

ArticleInternational journal of molecular sciences2021

Profiling Glioblastoma Cases with an Expression of DCX, OLIG2 and NES.

Adrian Odrzywolski, Bożena Jarosz, Michał Kiełbus, Ilona Telejko, Dominik Ziemianek, Sebastian Knaga, Radosław Rola

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Adrian OdrzywolskiDepartment of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0002-3370-8801
Bożena JaroszDepartment of Neurosurgery and Pediatric Neurosurgery, Medical University of Lublin, 20-090 Lublin, Poland.
Michał KiełbusDepartment of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093 Lublin, Poland.
Ilona TelejkoDepartment of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093 Lublin, Poland.
Dominik ZiemianekDepartment of Neurosurgery and Pediatric Neurosurgery, Medical University of Lublin, 20-090 Lublin, Poland.
Sebastian KnagaInstitute of Biological Bases of Animal Production, University of Life Sciences, 20-950 Lublin, Poland.ORCID 0000-0002-7176-3000
Radosław RolaDepartment of Neurosurgery and Pediatric Neurosurgery, Medical University of Lublin, 20-090 Lublin, Poland.ORCID 0000-0003-0613-6593
Medical University of Lublin · PLUniversity of Life Sciences in Lublin · PL

Funding

National Science Center 2015/17/N/NZ4/02839
6 · The paper itself

Abstract

Glioblastoma (GBM) remains the leading cause of cancer-related deaths with the lowest five-year survival rates among all of the human cancers. Multiple factors contribute to its poor outcome, including intratumor heterogeneity, along with migratory and invasive capacities of tumour cells. Over the last several years Doublecortin (DCX) has been one of the debatable factors influencing GBM cells' migration. To resolve DCX's ambiguous role in GBM cells' migration, we set to analyse the expression patterns of DCX along with Nestin (NES) and Oligodendrocyte lineage transcription factor 2 (OLIG2) in 17 cases of GBM, using immunohistochemistry, followed by an analysis of single-cell RNA-seq data. Our results showed that only a small subset of DCX positive (DCX

Indexed as

Brain NeoplasmsCell MovementDoublecortin ProteinGene Expression ProfilingGene Expression Regulation, NeoplasticGlioblastomaHeuristicsHumansImage Processing, Computer-AssistedMicroscopy, ConfocalNeoplasm MetastasisNeoplastic Stem CellsNestinOligodendrocyte Transcription Factor 2Sequence Analysis, RNASingle-Cell AnalysisDCX protein, humanDoublecortin ProteinNES protein, humanNestinOLIG2 protein, humanOligodendrocyte Transcription Factor 2brain tumoursDCXDoublecortinGlioblastomaimmunofluorescenceimmunohistochemistryNESOLIG2single cell RNA-seq

Identifiers

PMID34948016
PMCPMC8708973
OpenAlexW4200203861

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.