Evidence map›Paper›PMID 34948014›Full record

ArticleInternational journal of molecular sciences2021

Salt-Sensitive Hypertension in GR

Paul-Emmanuel Vanderriele, Qing Wang, Anne-Marie Mérillat, Frédérique Ino, Gilles Aeschlimann, Xavier Ehret, David Ancin Del Olmo, Verónica Ponce de León, Ute I Scholl, Denise V Winter and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. RSC advances · 2023
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Paul-Emmanuel VanderrieleDepartment of Biomedical Science, University of Lausanne, 1015 Lausanne, Switzerland.
Qing WangDivision of Nephrology and Hypertension, Lausanne University Hospital (CHUV), 1015 Lausanne, Switzerland.
Anne-Marie MérillatDepartment of Biomedical Science, University of Lausanne, 1015 Lausanne, Switzerland.
Frédérique InoDepartment of Biomedical Science, University of Lausanne, 1015 Lausanne, Switzerland.
Gilles AeschlimannDepartment of Biomedical Science, University of Lausanne, 1015 Lausanne, Switzerland.
Xavier EhretDepartment of Biomedical Science, University of Lausanne, 1015 Lausanne, Switzerland.
David Ancin Del OlmoDepartment of Biomedical Science, University of Lausanne, 1015 Lausanne, Switzerland.
Verónica Ponce de LeónDepartment of Biomedical Science, University of Lausanne, 1015 Lausanne, Switzerland.
Ute I SchollDepartment of Nephrology, School of Medicine, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany.
Denise V WinterNational Center of Competence in Research Kidney.CH, 8057 Zürich, Switzerland.
Alex OdermattNational Center of Competence in Research Kidney.CH, 8057 Zürich, Switzerland.ORCID 0000-0002-6820-2712
Edith HummlerDepartment of Biomedical Science, University of Lausanne, 1015 Lausanne, Switzerland.
Sophia N VeroutiDepartment of Biomedical Science, University of Lausanne, 1015 Lausanne, Switzerland.ORCID 0000-0002-2297-2738
University of Lausanne · CHUniversity of Basel · CHBerlin Institute of Health at Charité - Universitätsmedizin Berlin · DE

Funding

National Center of Competence in Research (NCCR) N-403-07-23Swiss National Science Foundation 31003A-182478/1
6 · The paper itself

Abstract

Mutations within the glucocorticoid receptor (GR) gene locus lead to glucocorticoid resistance which is characterized by several clinical symptoms such as adrenal gland hyperplasia and salt-sensitive hypertension, although the underlying mechanisms are still unknown. We studied GR haploinsufficient (GR

Indexed as

Adrenal GlandsAldosteroneAnimalsCorticosteroneEpoxide HydrolasesFatty Acids, UnsaturatedHaploinsufficiencyHyperplasiaHypertensionMaleRatsRats, Sprague-DawleyReceptors, GlucocorticoidSignal TransductionSodium Chloride, DietaryAldosteroneCorticosteroneEpoxide HydrolasesFatty Acids, UnsaturatedReceptors, GlucocorticoidSodium Chloride, Dietaryadrenal gland hyperplasiaChrousos syndromeglucocorticoid receptorglucocorticoid resistancehypertensionsoluble-epoxide hydrolase

Identifiers

PMID34948014
PMCPMC8708190
OpenAlexW4200290329

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.