Evidence map›Paper›PMID 34948001›Full record

ReviewInternational journal of molecular sciences2021

Ribosome Fate during Decoding of UGA-Sec Codons.

Paul R Copeland, Michael T Howard

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Selenoprotein K at the intersection of cellular pathways.Archives of biochemistry and biophysics · 2025
    Review
  3. Article
  4. Advances in the role of GPX3 in ovarian cancer (Review).International journal of oncology · 2024
    Article
  5. Biological and Catalytic Properties of Selenoproteins.International journal of molecular sciences · 2023
    Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Paul R CopelandDepartment of Biochemistry and Molecular Biology, Rutgers-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.ORCID 0000-0003-3343-0587
Michael T HowardDepartment of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA.
Rutgers, The State University of New Jersey · USUniversity of Utah · US

Funding

Functional Analysis of SBP2 and Selenocysteine IncorporationR01GM077073 · NIGMS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI COPELAND, PAUL R · 2006 to 2022
$5.5M
The effects of dietary selenium on translational control of protein synthesisR01GM114291 · NIGMS · UNIVERSITY OF UTAH · PI HOWARD, MICHAEL T · 2015 to 2022
$2.4M
NIGMS NIH HHS R01GM077073NIGMS NIH HHS R01 GM114291NIGMS NIH HHS R01GM114291
6 · The paper itself

Abstract

Decoding of genetic information into polypeptides occurs during translation, generally following the codon assignment rules of the organism's genetic code. However, recoding signals in certain mRNAs can overwrite the normal rules of translation. An exquisite example of this occurs during translation of selenoprotein mRNAs, wherein UGA codons are reassigned to encode for the 21st proteogenic amino acid, selenocysteine. In this review, we will examine what is known about the mechanisms of UGA recoding and discuss the fate of ribosomes that fail to incorporate selenocysteine.

Indexed as

AnimalsCodon, TerminatorGenetic CodeHumansProtein BiosynthesisRibosomesSelenocysteineSelenoproteinsCodon, TerminatorSelenocysteineSelenoproteinsnonsense-mediated decayrecodingribosome rescueSECISSECIS-binding proteinselenocysteineselenoproteintranslation termination

Identifiers

PMID34948001
PMCPMC8704476
OpenAlexW4200612856

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.