Evidence map›Paper›PMID 34948000›Full record

ArticleInternational journal of molecular sciences2021

Increased Expression of Flightless I in Cutaneous Squamous Cell Carcinoma Affects Wnt/β-Catenin Signaling Pathway.

Gink N Yang, Xanthe L Strudwick, Claudine S Bonder, Zlatko Kopecki, Allison J Cowin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Gink N YangFuture Industries Institute, University of South Australia, Adelaide 5095, Australia.
Xanthe L StrudwickFuture Industries Institute, University of South Australia, Adelaide 5095, Australia.ORCID 0000-0002-8557-3857
Claudine S BonderCenter for Cancer Biology, University of South Australia and SA Pathology, Adelaide 5000, Australia.ORCID 0000-0001-9875-967X
Zlatko KopeckiFuture Industries Institute, University of South Australia, Adelaide 5095, Australia.ORCID 0000-0002-8072-4222
Allison J CowinFuture Industries Institute, University of South Australia, Adelaide 5095, Australia.ORCID 0000-0003-2885-2080
University of South Australia · AUSouth Australia Pathology · AU

Funding

Channrl 7 Children's Research Foundation KopeckiNational Health and Medical Research Council 1102617
6 · The paper itself

Abstract

Cutaneous squamous cell carcinoma (cSCC) accounts for 25% of cutaneous malignancies diagnosed in Caucasian populations. Surgical removal in combination with radiation and chemotherapy are effective treatments for cSCC. Nevertheless, the aggressive metastatic forms of cSCC still have a relatively poor patient outcome. Studies have linked actin cytoskeletal dynamics and the Wnt/β-catenin signaling pathway as important modulators of cSCC pathogenesis. Previous studies have also shown that the actin-remodeling protein Flightless (Flii) is a negative regulator of cSCC. The aim of this study was to investigate if the functional effects of Flii on cSCC involve the Wnt/β-catenin signaling pathway. Flii knockdown was performed using siRNA in a human late stage aggressive metastatic cSCC cell line (MET-1) alongside analysis of

Indexed as

Up-RegulationWnt Signaling PathwayAnimalsCarcinoma, Squamous CellCell Line, TumorCell ProliferationDisease Models, AnimalFemaleGene Expression Regulation, NeoplasticGene Knockdown TechniquesHumansMethylcholanthreneMiceMicrofilament ProteinsSkin NeoplasmsTrans-ActivatorsFLII protein, humanMethylcholanthreneMicrofilament ProteinsTrans-Activatorscancer metastasisFlightlessnon-melanoma skin cancersquamous cell carcinoma

Identifiers

PMID34948000
PMCPMC8703548
OpenAlexW4200134446

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.