Evidence map›Paper›PMID 34947982›Full record

ArticleInternational journal of molecular sciences2021

eIF5A-Independent Role of DHPS in p21

Andrew E Becker, Pui-Kei Wu, Jong-In Park

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. What Is All of the Hype About? Hypusine Signaling as a Driver of Pulmonary Hypertension.American journal of respiratory and critical care medicine · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Andrew E BeckerDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Pui-Kei WuDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0002-8734-2657
Jong-In ParkDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0001-7248-4735
Medical College of Wisconsin · US

Funding

Mechanisms of MEK/ERK growth arrest signalingR01CA138441 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI PARK, JONG-IN · 2010 to 2020
$2.9M
NCI NIH HHS R01 CA138441NCI NIH HHS R01CA138441
6 · The paper itself

Abstract

Deoxyhypusine synthase (DHPS) catalyzes the first step of hypusination of the elongation translation factor 5A (eIF5A), and these two proteins have an exclusive enzyme-substrate relationship. Here we demonstrate that DHPS has a role independent of eIF5A hypusination in A375 and SK-MEL-28 human melanoma cells, in which the extracellular signal regulated kinase 1/2 (ERK1/2) pathway is deregulated. We found that RNA interference of DHPS induces G0/G1 cell cycle arrest in association with increased p21

Indexed as

ApoptosisCell Cycle CheckpointsCell Line, TumorCell ProliferationCyclin-Dependent Kinase Inhibitor p21Eukaryotic Translation Initiation Factor 5AGene Expression Regulation, NeoplasticGene Knockout TechniquesHEK293 CellsHumansMAP Kinase Signaling SystemMutationNeoplasmsOxidoreductases Acting on CH-NH Group DonorsPeptide Initiation FactorsRNA-Binding ProteinsCDKN1A protein, humanCyclin-Dependent Kinase Inhibitor p21deoxyhypusine synthaseEukaryotic Translation Initiation Factor 5AOxidoreductases Acting on CH-NH Group DonorsPeptide Initiation FactorsRNA-Binding ProteinsBRAFcell deathdeoxyhypusine synthaseERK1/2eukaryotic initiation factor 5Agrowth arrestp21CIP1

Identifiers

PMID34947982
PMCPMC8707118
OpenAlexW4200224130

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.