Evidence map›Paper›PMID 34947939›Full record

ArticleLife (Basel, Switzerland)2021

The Cell Protective Effect of Adenine on Hypoxia-Reoxygenation Injury through PPAR Delta Activation.

Jyh-Gang Leu, Chien-Mei Wang, Chao-Yi Chen, Yi-Feng Yang, Chin-Yu Shih, Jiun-Tsai Lin, Han-Min Chen, Yao-Jen Liang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Protective Effect ofFood science & nutrition · 2026
    Article
  2. Topical Application ofLife (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jyh-Gang LeuSchool of Medicine, Fu-Jen Catholic University, New Taipei City 24205, Taiwan.
Chien-Mei WangDepartment and Institute of Life Science, Fu-Jen Catholic University, New Taipei City 24205, Taiwan.
Chao-Yi ChenGraduate Institute of Applied Science and Engineering, Fu-Jen Catholic University, New Taipei City 24205, Taiwan.
Yi-Feng YangGraduate Institute of Applied Science and Engineering, Fu-Jen Catholic University, New Taipei City 24205, Taiwan.
Chin-Yu ShihGraduate Institute of Applied Science and Engineering, Fu-Jen Catholic University, New Taipei City 24205, Taiwan.
Jiun-Tsai LinEnergenesis Biomedical Co., Ltd., Taipei 11492, Taiwan.
Han-Min ChenDepartment and Institute of Life Science, Fu-Jen Catholic University, New Taipei City 24205, Taiwan.
Yao-Jen LiangGraduate Institute of Applied Science and Engineering, Fu-Jen Catholic University, New Taipei City 24205, Taiwan.
Fu Jen Catholic University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemia followed by blood supply reperfusion in cardiomyocytes leads to an overproduction of free radicals and a rapid decrease of adenosine triphosphate concentration. The cardioprotective effect of a potential drug, adenine, was evaluated using H9c2 rat cardiomyoblasts. After hypoxia-reoxygenation (HR) treatment consisting of hypoxia for 21 h followed by reoxygenation for 6 h, it was revealed that pretreatment with 200 µM adenine for 2 h effectively prevented HR-induced cell death. Adenine also significantly decreased the production of reactive oxygen species and reduced cell apoptosis after HR injury. The antioxidant effect of adenine was also revealed in this study. Adenine pretreatment significantly reduced the expression of activating transcription factor 4 (ATF4) and glucose-regulated protein 78 (GRP78) proteins, and protein disulfide isomerase induced a protective effect on mitochondria after HR stimulation. Intracellular adenosine monophosphate-activated protein kinase, peroxisome proliferator-activated receptor delta (PPARδ), and perilipin levels were increased by adenine after HR stimulation. Adenine had a protective effect in HR-damaged H9c2 cells. It may be used in multiple preventive medicines in the future.

Indexed as

adenineantioxidationcell cycleischemia-reperfusionmyocardial infarction

Identifiers

PMID34947939
PMCPMC8703696
OpenAlexW4200523198

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.