Evidence map›Paper›PMID 34947929›Full record

ArticleLife (Basel, Switzerland)2021

Deficiency of MMP-10 Aggravates the Diseased Phenotype of Aged Dystrophic Mice.

Arantxa Baraibar-Churio, Míriam Bobadilla, Florencio J D Machado, Neira Sáinz, Carmen Roncal, Gloria Abizanda, Felipe Prósper, Josune Orbe, Ana Pérez-Ruiz

Open access · goldAbstract read
In one paragraph

Article in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Arantxa Baraibar-ChurioRegenerative Medicine Program, Foundation for Applied Medical Research (FIMA), University of Navarra, 31009 Pamplona, Spain.
Míriam BobadillaRegenerative Medicine Program, Foundation for Applied Medical Research (FIMA), University of Navarra, 31009 Pamplona, Spain.ORCID 0000-0002-7719-3483
Florencio J D MachadoInstituto de Investigación Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain.ORCID 0000-0002-2495-0786
Neira SáinzRegenerative Medicine Program, Foundation for Applied Medical Research (FIMA), University of Navarra, 31009 Pamplona, Spain.
Carmen RoncalInstituto de Investigación Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain.ORCID 0000-0003-0616-9600
Gloria AbizandaRegenerative Medicine Program, Foundation for Applied Medical Research (FIMA), University of Navarra, 31009 Pamplona, Spain.
Felipe PrósperRegenerative Medicine Program, Foundation for Applied Medical Research (FIMA), University of Navarra, 31009 Pamplona, Spain.ORCID 0000-0001-6115-8790
Josune OrbeInstituto de Investigación Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain.ORCID 0000-0001-6300-7670
Ana Pérez-RuizRegenerative Medicine Program, Foundation for Applied Medical Research (FIMA), University of Navarra, 31009 Pamplona, Spain.
Navarre Institute of Health Research · ES

Funding

Spanish Ministry of Health PI081919
6 · The paper itself

Abstract

Matrix metalloproteinases (MMPs) have been implicated in the progression of muscular dystrophy, and recent studies have reported the role of MMP-10 in skeletal muscle pathology of young dystrophic mice. Nevertheless, its involvement in dystrophin-deficient hearts remains unexplored. Here, we aimed to investigate the involvement of MMP-10 in the progression of severe muscular dystrophy and to characterize MMP-10 loss in skeletal and cardiac muscles of aged dystrophic mice. We examined the histopathological effect of MMP-10 ablation in aged

Indexed as

cardiac musclematrix metalloproteinasesmuscular dystrophyskeletal muscle

Identifiers

PMID34947929
PMCPMC8705381
OpenAlexW4226062738

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.