ArticleLife (Basel, Switzerland)2021
Distribution and Appearance of Ki-67, IL-1α, IL-10, and PGP 9.5 in Reinke's Oedema-Affected Larynx Tissue Compared with Control Tissue.
Article in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 3 citations in OpenAlex.
- Laryngeal Basal Cell Response to Cigarette Smoke and E-Cigarette Aerosol Exposures.The Laryngoscope · 2026Article
- Antimicrobial and Defense Proteins in Chronic Rhinosinusitis with Nasal Polyps.Medicina (Kaunas, Lithuania) · 2023Article
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4 authors at 2 institutions in 1 country.
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Abstract
Smoking, laryngopharyngeal reflux, and vocal fold abuse can promote the development of Reinke's oedema, leading to vocal fold dysfunction and injury. The aim of the work was to investigate the appearance and distribution of proliferation marker Ki-67 (Ki-67), interleukin 10 (IL-10), interleukin 1 alpha (IL-1α), and protein gene peptide 9.5 (PGP 9.5) in Reinke's oedema-affected larynx tissue.
methodsA routine histological and immunohistochemical Reinke's oedema and control group patient analysis was conducted. We used the biotin-streptavidin biochemical method to detect Ki-67, IL-10, IL-1α, and PGP 9.5 The semiquantitative grading method was used to evaluate immunoreactive cells' appearance and local distribution. A Mann-Whitney U test and Spearman's rank coefficient were performed.
resultsA low positive correlation between IL-1α epithelial and subepithelial immunoreactive cells in the patient group was found. Mann-Whitney U tests revealed significant patient and control group immunoreactive marker differences. All examined markers showed a higher number of immunoreactive structures in the patient group.
conclusionsIntensive proliferation of the surface epithelium was observed in patient tissues. The notable increase in IL-10 positive structures indicates the dominant anti-inflammatory tissue response. An increased number of IL-1α structures in the larynx epithelium and subepithelium in the patient group is linked to inflammation, proliferation, and tissue remodelling. The PGP 9.5 expression increase is involved in the morphopathogenesis of Reinke's oedema.
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