ReviewLife (Basel, Switzerland)2021
The Role of Pediatric Nutrition as a Modifiable Risk Factor for Precocious Puberty.
Review in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Postnatal Bisphenol A exposure and risk of precocious puberty in children: updated systematic review and meta-analysis.Frontiers in public health · 2026Pooled it
- Diet and Nutrients Intakes during Infancy and Childhood in Relation to Early Puberty: A Systematic Review and Meta-Analysis.Nutrients · 2022Pooled it
- BMI-SDS Changes During GnRHa Therapy in 150 Girls with Idiopathic Central Precocious Puberty: Follow-up Through Final HeightJournal of clinical research in pediatric endocrinology · 2026Article
- Longitudinal and Bidirectional Relationships Between Sleep, Emotional Wellbeing and Weight Status in Childhood and Adolescence: Growing Up in Scotland Cohort Analysis.Journal of sleep research · 2026Article
- Unveiling the gut: microbiota and derived metabolites' role in the rising tide of precocious puberty.Frontiers in microbiology · 2026Review
- Hypothalamic neuroimmune remodeling as an immunometabolic bridge between childhood obesity and earlier pubertal onset.Frontiers in immunology · 2026Review
- Risk factors and preventive strategies for precocious puberty: a narrative review.Frontiers in pediatrics · 2026Review
- Puberty Starts in the Gut: Intestinal Clues to Early Puberty-Rethinking Biomarkers in Pediatric Endocrinology.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Analysis of Tanner stage in children conceived after the diagnosis of infertility: the DESCRT study.Journal of assisted reproduction and genetics · 2025Article
- Article
- Development and comparison of multivariate diagnostic models for rapidly progressive central precocious puberty in girls: the role of serum osteocalcin.Frontiers in endocrinology · 2025Article
- ADHD and Risk of Precocious Puberty: Considering the Impact of MPH.Biomedicines · 2024Article
- Evaluating Phthalates and Bisphenol in Foods: Risks for Precocious Puberty and Early-Onset Obesity.Nutrients · 2024Review
- Ultra-processed foods intake and sex hormone levels among children and adolescents aged 6-19 years: a cross-sectional study.Frontiers in nutrition · 2024Article
- Characterization of MicroRNA expression profiles in the ovarian tissue of goats during the sexual maturity period.Journal of ovarian research · 2023Article
- Breast and Formula Milk and Early Puberty Onset.Children (Basel, Switzerland) · 2023Review
- Association between Vitamin D Levels, Puberty Timing, and Age at Menarche.Children (Basel, Switzerland) · 2023Review
- The Impact of Modifiable Environmental, Nutritional, and Lifestyle Factors on Puberty, Reproductive Function, and Fertility in Children and Adolescents.Children (Basel, Switzerland) · 2023Article
- Reproducibility and Validity of a Semi-Quantitative Food Frequency Questionnaire for Children Aged 6-12 in Western China.Nutrients · 2023Article
- Links between Childhood Obesity, High-Fat Diet, and Central Precocious Puberty.Children (Basel, Switzerland) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Puberty is a critical phase of growth and development characterized by a complex process regulated by the neuroendocrine system. Precocious puberty (PP) is defined as the appearance of physical and hormonal signs of pubertal development at an earlier age than is considered normal. The timing of puberty has important public health, clinical, and social implications. In fact, it is crucial in psychological and physical development and can impact future health. Nutritional status is considered as one of the most important factors modulating pubertal development. This narrative review presents an overview on the role of nutritional factors as determinants of the timing of sexual maturation, focusing on early-life and childhood nutrition. As reported, breast milk seems to have an important protective role against early puberty onset, mainly due to its positive influence on infant growth rate and childhood overweight prevention. The energy imbalance, macro/micronutrient food content, and dietary patterns may modulate the premature activation of the hypothalamic-pituitary-gonadal axis, inducing precocious activation of puberty. An increase in knowledge on the mechanism whereby nutrients may influence puberty will be useful in providing adequate nutritional recommendations to prevent PP and related complications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.