Evidence map›Paper›PMID 34947882›Full record

ReviewLife (Basel, Switzerland)2021

Mitochondria and Their Relationship with Common Genetic Abnormalities in Hematologic Malignancies.

Ibolya Czegle, Austin L Gray, Minjing Wang, Yan Liu, Jun Wang, Edina A Wappler-Guzzetta

Abstract readReview
In one paragraph

Review in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Subcellular Stress Markers in Epithelial Ovarian Cancer.International journal of molecular sciences · 2025
    Review
  3. Article
  4. Mitochondria and Acute Leukemia: A Clinician's Perspective.International journal of molecular sciences · 2024
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ibolya CzegleDepartment of Internal Medicine and Haematology, Semmelweis University, H-1085 Budapest, Hungary.
Austin L GrayDepartment of Pathology and Laboratory Medicine, Loma Linda University Health, Loma Linda, CA 92354, USA.ORCID 0000-0003-4930-9423
Minjing WangIndependent Researcher, Diamond Bar, CA 91765, USA.
Yan LiuDepartment of Pathology and Laboratory Medicine, Loma Linda University Health, Loma Linda, CA 92354, USA.
Jun WangDepartment of Pathology and Laboratory Medicine, Loma Linda University Health, Loma Linda, CA 92354, USA.
Edina A Wappler-GuzzettaDepartment of Pathology and Laboratory Medicine, Loma Linda University Health, Loma Linda, CA 92354, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hematologic malignancies are known to be associated with numerous cytogenetic and molecular genetic changes. In addition to morphology, immunophenotype, cytochemistry and clinical characteristics, these genetic alterations are typically required to diagnose myeloid, lymphoid, and plasma cell neoplasms. According to the current World Health Organization (WHO) Classification of Tumors of Hematopoietic and Lymphoid Tissues, numerous genetic changes are highlighted, often defining a distinct subtype of a disease, or providing prognostic information. This review highlights how these molecular changes can alter mitochondrial bioenergetics, cell death pathways, mitochondrial dynamics and potentially be related to mitochondrial genetic changes. A better understanding of these processes emphasizes potential novel therapies.

Indexed as

fission-fusiongenetic abnormalitieshematological malignanciesmetabolismmitochondriatherapeutic targets

Identifiers

PMID34947882
PMCPMC8707674

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.