Evidence map›Paper›PMID 34947788›Full record

ArticleNanomaterials (Basel, Switzerland)2021

Green Hydrogels Composed of Sodium Mannuronate/Guluronate, Gelatin and Biointeractive Calcium Silicates/Dicalcium Phosphate Dihydrate Designed for Oral Bone Defects Regeneration.

Maria Giovanna Gandolfi, Fausto Zamparini, Sabrina Valente, Greta Parchi, Gianandrea Pasquinelli, Paola Taddei, Carlo Prati

Open access · goldAbstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Maria Giovanna GandolfiLaboratory of Green Biomaterials and Oral Pathology, School of Dentistry, DIBINEM, University of Bologna, 40125 Bologna, Italy.ORCID 0000-0001-7793-6227
Fausto ZampariniLaboratory of Green Biomaterials and Oral Pathology, School of Dentistry, DIBINEM, University of Bologna, 40125 Bologna, Italy.ORCID 0000-0002-0071-4463
Sabrina ValenteDepartment of Experimental, Diagnostic and Specialty Medicine, DIMES, University of Bologna, 40138 Bologna, Italy.
Greta ParchiLaboratory of Green Biomaterials and Oral Pathology, School of Dentistry, DIBINEM, University of Bologna, 40125 Bologna, Italy.ORCID 0000-0002-7764-4539
Gianandrea PasquinelliDepartment of Experimental, Diagnostic and Specialty Medicine, DIMES, University of Bologna, 40138 Bologna, Italy.ORCID 0000-0003-1506-1829
Paola TaddeiBiochemistry Unit, DIBINEM, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0001-8478-4508
Carlo PratiEndodontic Clinical Section, School of Dentistry, DIBINEM, University of Bologna, 40125 Bologna, Italy.
University of Bologna · ITAzienda USL di Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Innovative green, eco-friendly, and biologically derived hydrogels for non-load bearing bone sites were conceived and produced. Natural polysaccharides (copolymers of sodium D-mannuronate and L-guluronate) with natural polypeptides (gelatin) and bioactive mineral fillers (calcium silicates CaSi and dicalcium phosphate dihydrate DCPD) were used to obtain eco-sustainable biomaterials for oral bone defects. Three PP-x:y formulations were prepared (PP-16:16, PP-33:22, and PP-31:31), where PP represents the polysaccharide/polypeptide matrix and x and y represent the weight % of CaSi and DCPD, respectively. Hydrogels were tested for their chemical-physical properties (calcium release and alkalizing activity in deionized water, porosity, solubility, water sorption, radiopacity), surface microchemistry and micromorphology, apatite nucleation in HBSS by ESEM-EDX, FT-Raman, and micro-Raman spectroscopies. The expression of vascular (

Indexed as

algae-based hydrogelsbioactive mineralsbone regenerationcalcium silicates (CaSi)dicalcium phosphate dihydrate (DCPD)green biomaterialsnatural polymersnatural polysaccaridesoral bone defectsregenerative medicineseaweed-based hydrogelstissue engineering

Identifiers

PMID34947788
PMCPMC8706657
OpenAlexW4200615875

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.