Evidence map›Paper›PMID 34947600›Full record

ArticleNanomaterials (Basel, Switzerland)2021

Biocompatibility Testing of Liquid Metal as an Interconnection Material for Flexible Implant Technology.

Katharina Foremny, Steven Nagels, Michaela Kreienmeyer, Theodor Doll, Wim Deferme

Open access · goldAbstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Liquid Metal Patterning and Unique Properties for Next-Generation Soft Electronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  9. Responsive Liquid Metal Droplets: From Bulk to Nano.Nanomaterials (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Katharina ForemnyORL Department, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.
Steven NagelsInstitute for Materials Research (IMO), Hasselt University, Wetenschapspark 1, 3590 Diepenbeek, Belgium.
Michaela KreienmeyerORL Department, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.
Theodor DollORL Department, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.
Wim DefermeInstitute for Materials Research (IMO), Hasselt University, Wetenschapspark 1, 3590 Diepenbeek, Belgium.ORCID 0000-0002-8982-959X
Medizinische Hochschule Hannover · DEIMEC · BE

Funding

Deutsche Forschungsgemeinschaft EXC2177Vlaams Agentschap voor Innovatie en Ontwikkeling HBC.2018.2111
6 · The paper itself

Abstract

Galinstan, a liquid metal at room temperature, is a promising material for use in flexible electronics. Since it has been successfully integrated in devices for external use, e.g., as stretchable electronic skin in tactile sensation, the possibility of using galinstan for flexible implant technology comes to mind. Usage of liquid metals in a flexible implant would reduce the risk of broken conductive pathways in the implants and therefore reduce the possibility of implant failure. However, the biocompatibility of the liquid metal under study, i.e., galinstan, has not been proven in state-of-the-art literature. Therefore, in this paper, a material combination of galinstan and silicone rubber is under investigation regarding the success of sterilization methods and to establish biocompatibility testing for an in vivo application. First cell biocompatibility tests (WST-1 assays) and cell toxicity tests (LDH assays) show promising results regarding biocompatibility. This work paves the way towards the successful integration of stretchable devices using liquid metals embedded in a silicone rubber encapsulant for flexible surface electro-cortical grid arrays and other flexible implants.

Indexed as

bacteriabiocompatibilitygalinstanin-vivosilicone rubbersterilization

Identifiers

PMID34947600
PMCPMC8706733
OpenAlexW3215394489

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.