Evidence map›Paper›PMID 34947534›Full record

ArticleNanomaterials (Basel, Switzerland)2021

Analysis of Fluorescence Decay Kinetics of Indocyanine Green Monomers and Aggregates in Brain Tumor Model In Vivo.

Dina Farrakhova, Igor Romanishkin, Yuliya Maklygina, Lina Bezdetnaya, Victor Loschenov

Open access · goldAbstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Nanomaterials for Drug Delivery and Cancer Therapy.Nanomaterials (Basel, Switzerland) · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Dina FarrakhovaProkhorov General Physics Institute of the Russian Academy of Science, 119991 Moscow, Russia.ORCID 0000-0001-9519-0561
Igor RomanishkinProkhorov General Physics Institute of the Russian Academy of Science, 119991 Moscow, Russia.ORCID 0000-0002-7986-3460
Yuliya MaklyginaProkhorov General Physics Institute of the Russian Academy of Science, 119991 Moscow, Russia.
Lina BezdetnayaCentre de Recherche en Automatique de Nancy, CNRS, Université de Lorraine, 54519 Vandoeuvre-lès-Nancy, France.
Victor LoschenovProkhorov General Physics Institute of the Russian Academy of Science, 119991 Moscow, Russia.
Prokhorov General Physics Institute · RUCentre National de la Recherche Scientifique · FRInstitute of Engineering Physics · RU

Funding

IEA (International Emerging Action) CNRS grant 00534Russian Foundation for Basic Research 21-52-15025
6 · The paper itself

Abstract

Spectroscopic approach with fluorescence time resolution allows one to determine the state of a brain tumor and its microenvironment via changes in the fluorescent dye's fluorescence lifetime. Indocyanine green (ICG) is an acknowledged infra-red fluorescent dye that self-assembles into stable aggregate forms (ICG NPs). ICG NPs aggregates have a tendency to accumulate in the tumor with a maximum accumulation at 24 h after systemic administration, enabling extended intraoperative diagnostic. Fluorescence lifetime analysis of ICG and ICG NPs demonstrates different values for ICG monomers and H-aggregates, indicating promising suitability for fluorescent diagnostics of brain tumors due to their affinity to tumor cells and stability in biological tissue.

Indexed as

brain cancerfluorescent diagnosisfluorescent dyesfluorescent lifetimeglioma C6H-aggregatesindocyanine greennear-infrared range

Identifiers

PMID34947534
PMCPMC8709123
OpenAlexW3216597233

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.