Evidence map›Paper›PMID 34947529›Full record

ArticleNanomaterials (Basel, Switzerland)2021

Encapsulation of Photothermal Nanoparticles in Stealth and pH-Responsive Micelles for Eradication of Infectious Biofilms In Vitro and In Vivo.

Ruifang Gao, Linzhu Su, Tianrong Yu, Jian Liu, Henny C van der Mei, Yijin Ren, Gaojian Chen, Linqi Shi, Brandon W Peterson, Henk J Busscher

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Ruifang GaoCollege of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215006, China.
Linzhu SuUniversity of Groningen, University Medical Center Groningen, Department of Biomedical Engineering, 9713 AV Groningen, The Netherlands.
Tianrong YuUniversity of Groningen, University Medical Center Groningen, Department of Biomedical Engineering, 9713 AV Groningen, The Netherlands.
Jian LiuJiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou 215006, China.
Henny C van der MeiUniversity of Groningen, University Medical Center Groningen, Department of Biomedical Engineering, 9713 AV Groningen, The Netherlands.ORCID 0000-0003-0760-8900
Yijin RenUniversity of Groningen, University Medical Center Groningen, Department of Orthodontics, 9713 AV Groningen, The Netherlands.ORCID 0000-0002-2374-1771
Gaojian ChenCollege of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215006, China.ORCID 0000-0002-5877-3159
Linqi ShiKey Laboratory of Functional Polymer Materials of Ministry of Education State, Key Laboratory of Medicinal Chemical Biology, Institute of Polymer Chemistry College of Chemistry, Nankai University, Tianjin 300071, China.
Brandon W PetersonUniversity of Groningen, University Medical Center Groningen, Department of Biomedical Engineering, 9713 AV Groningen, The Netherlands.
Henk J BusscherUniversity of Groningen, University Medical Center Groningen, Department of Biomedical Engineering, 9713 AV Groningen, The Netherlands.ORCID 0000-0002-3644-5533
University Medical Center Groningen · NLSoochow University · CNNankai University · CN

Funding

National Natural Science Foundation of China 21935008University Medical Center Groningen not applicable
6 · The paper itself

Abstract

Photothermal nanoparticles can be used for non-antibiotic-based eradication of infectious biofilms, but this may cause collateral damage to tissue surrounding an infection site. In order to prevent collateral tissue damage, we encapsulated photothermal polydopamine-nanoparticles (PDA-NPs) in mixed shell polymeric micelles, composed of stealth polyethylene glycol (PEG) and pH-sensitive poly(β-amino ester) (PAE). To achieve encapsulation, PDA-NPs were made hydrophobic by electrostatic binding of indocyanine green (ICG). Coupling of ICG enhanced the photothermal conversion efficacy of PDA-NPs from 33% to 47%. Photothermal conversion was not affected by micellar encapsulation. No cytotoxicity or hemolytic effects of PEG-PAE encapsulated PDA-ICG-NPs were observed. PEG-PAE encapsulated PDA-ICG-NPs showed good penetration and accumulation in a

Indexed as

biofilminfectionmicellesphotothermal nanoparticlespolydopamineself-targeting

Identifiers

PMID34947529
PMCPMC8706488
OpenAlexW3217620955

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.