Evidence map›Paper›PMID 34946965›Full record

ArticleGenes2021

miR-143 Targeting CUX1 to Regulate Proliferation of Dermal Papilla Cells in Hu Sheep.

Tingyan Hu, Sainan Huang, Xiaoyang Lv, Shanhe Wang, Tesfaye Getachew, Joram M Mwacharo, Aynalem Haile, Wei Sun

Open access · goldAbstract read
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Tingyan HuCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Sainan HuangCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Xiaoyang LvJoint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Yangzhou University, Yangzhou 225009, China.
Shanhe WangCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Tesfaye GetachewInternational Centre for Agricultural Research in the Dry Areas, Addis Ababa 999047, Ethiopia.
Joram M MwacharoInternational Centre for Agricultural Research in the Dry Areas, Addis Ababa 999047, Ethiopia.
Aynalem HaileInternational Centre for Agricultural Research in the Dry Areas, Addis Ababa 999047, Ethiopia.
Wei SunCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
Yangzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wool curvature is the determining factor for lambskin quality of Hu lambs. However, the molecular mechanism of wool curvature formation is not yet known. miRNA has been proved to play an important role in hair follicle development, and we have discovered a differentially expressed miRNA, miR-143, in hair follicles of different curl levels. In this study, we first examined the effects of miR-143 on the proliferation and cell cycle of dermal papilla cells using CCK8, EdU and flow cytometry and showed that miR-143 inhibited the proliferation of dermal papilla cells and slowed down the cell cycle. Bioinformatics analysis was performed to predict the target genes

Indexed as

AnimalsCell ProliferationCells, CulturedComputational BiologyGene Expression ProfilingGene Expression RegulationHair FollicleHomeodomain ProteinsMicroRNAsSheepHomeodomain ProteinsMicroRNAsCUX1dermal papilla cellKRT71miR-143proliferationwool curvature

Identifiers

PMID34946965
PMCPMC8700861
OpenAlexW4200474063

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.