Evidence map›Paper›PMID 34946949›Full record

ArticleGenes2021

Spatial and Temporal Expression of High-Mobility-Group Nucleosome-Binding (HMGN) Genes in Brain Areas Associated with Cognition in Individuals with Down Syndrome.

Alejandra Rodríguez-Ortiz, Julio César Montoya-Villegas, Felipe García-Vallejo, Yecid Mina-Paz

Open access · goldAbstract read
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Alejandra Rodríguez-OrtizLaboratory of Molecular Biology and Pathogenesis, Department of Physiological Sciences, School of Basic Sciences, Faculty of Health, Universidad del Valle, Cali 76001, Colombia.ORCID 0000-0003-1369-2328
Julio César Montoya-VillegasLaboratory of Molecular Biology and Pathogenesis, Department of Physiological Sciences, School of Basic Sciences, Faculty of Health, Universidad del Valle, Cali 76001, Colombia.
Felipe García-VallejoLaboratory of Molecular Biology and Pathogenesis, Department of Physiological Sciences, School of Basic Sciences, Faculty of Health, Universidad del Valle, Cali 76001, Colombia.
Yecid Mina-PazHealth and Movement Research Group, Faculty of Health, Universidad Santiago de Cali, Cali 76001, Colombia.ORCID 0000-0002-0623-1526
Universidad del Valle · COUniversidad Santiago de Cali · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA methylation and histone posttranslational modifications are epigenetics processes that contribute to neurophenotype of Down Syndrome (DS). Previous reports present strong evidence that nonhistone high-mobility-group N proteins (HMGN) are epigenetic regulators. They play important functions in various process to maintain homeostasis in the brain. We aimed to analyze the differential expression of five human HMGN genes in some brain structures and age ranks from DS postmortem brain samples.

Indexed as

BrainBrain MappingCognitionDatabases, GeneticDown SyndromeEpigenesis, GeneticGene ExpressionGene Expression ProfilingGene Expression RegulationHippocampusHMGN1 ProteinHMGN2 ProteinHMGN ProteinsHumansNucleosomesPrefrontal CortexHMGN1 ProteinHMGN2 ProteinHMGN5 protein, humanHMGN ProteinsNucleosomesTrans-ActivatorsTranscription FactorsDown Syndromeepigeneticsgene expressionhigh-mobility-group N proteins (HMGN)human brainneuroinformatics

Identifiers

PMID34946949
PMCPMC8700945
OpenAlexW4225777018

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.