Evidence map›Paper›PMID 34946922›Full record

ArticleGenes2021

Microarray Genotyping Identifies New Loci Associated with Dementia in Parkinson's Disease.

Sungyang Jo, Kye Won Park, Yun Su Hwang, Seung Hyun Lee, Ho-Sung Ryu, Sun Ju Chung

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Association ofAlzheimer's & dementia (New York, N. Y.)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Sungyang JoDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.ORCID 0000-0001-5097-2340
Kye Won ParkDepartment of Neurology, Uijeongbu Eulji Medical Center, Eulji University School of Medicine, Uijeongbu-si 11759, Gyeonggi-do, Korea.
Yun Su HwangDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Seung Hyun LeeDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Ho-Sung RyuDepartment of Neurology, Kyungpook National University Hospital, Daegu 41944, Korea.
Sun Ju ChungDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Ulsan College · KREulji University · KRKyungpook National University Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dementia is one of the most disabling nonmotor symptoms of Parkinson's disease (PD). However, the risk factors contributing to its development remain unclear. To investigate genetic variants associated with dementia in PD, we performed microarray genotyping based on a customized platform utilizing variants identified in previous genetic studies. Microarray genotyping was performed in 313 PD patients with dementia, 321 PD patients without dementia, and 635 healthy controls. The primary analysis was performed using a multiple logistic regression model adjusted for age and sex.

Indexed as

AgedAged, 80 and overDementiaFemaleGenetic Predisposition to DiseaseGenotypeHeat-Shock ProteinsHumansMaleMiddle AgedOdds RatioParkinson DiseasePolymorphism, Single NucleotideProspective StudiesRisk FactorsTranscription FactorsHeat-Shock ProteinsTranscription Factorscognitiondementiagenome-wide association studyParkinson’s disease

Identifiers

PMID34946922
PMCPMC8701809
OpenAlexW4200582376

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.