Evidence map›Paper›PMID 34946910›Full record

ArticleGenes2021

A Precise Method to Evaluate 360 Degree Measures of Optic Cup and Disc Morphology in an African American Cohort and Its Genetic Applications.

Victoria Addis, Min Chen, Richard Zorger, Rebecca Salowe, Ebenezer Daniel, Roy Lee, Maxwell Pistilli, Jinpeng Gao, Maureen G Maguire, Lilian Chan and 11 more

Open access · goldAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 73% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 3 institutions in 1 country.

Victoria AddisScheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Min ChenDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Richard ZorgerPenn Vision Research Center, University of Pennsylvania, Philadelphia, PA 19104, USA.
Rebecca SaloweScheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ebenezer DanielScheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Roy LeeScheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Maxwell PistilliScheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jinpeng GaoScheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Maureen G MaguireScheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Lilian ChanScheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Harini V GudisevaScheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Selam Zenebe-GeteScheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Sayaka MerriamScheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Eli J SmithScheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Revell MartinScheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Candace Parker OstroffScheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
James C GeeDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Qi N CuiScheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Eydie Miller-EllisScheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Joan M O'BrienScheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Prithvi S SankarScheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Penn Presbyterian Medical Center · USUniversity of Pennsylvania · USPenn Center for AIDS Research · US

Funding

Scientific TransparencyP30EY001583 · NEI · UNIVERSITY OF PENNSYLVANIA · PI Qi N Cui · 1985 to 2026
$19.5M
Primary Open Angle African-American Glaucoma Genetics Study RenewalR01EY023557 · NEI · UNIVERSITY OF PENNSYLVANIA · PI O'BRIEN, JOAN M · 2014 to 2025
$18.1M
NEI NIH HHS P30 EY001583NEI NIH HHS R01 EY023557
6 · The paper itself

Abstract

(1) Background: Vertical cup-to-disc ratio (CDR) is an important measure for evaluating damage to the optic nerve head (ONH) in glaucoma patients. However, this measure often does not fully capture the irregular cupping observed in glaucomatous nerves. We developed and evaluated a method to measure cup-to-disc ratio (CDR) at all 360 degrees of the ONH. (2) Methods: Non-physician graders from the Scheie Reading Center outlined the cup and disc on digital stereo color disc images from African American patients enrolled in the Primary Open-Angle African American Glaucoma Genetics (POAAGG) study. After converting the resultant coordinates into polar representation, the CDR at each 360-degree location of the ONH was obtained. We compared grader VCDR values with clinical VCDR values, using Spearman correlation analysis, and validated significant genetic associations with clinical VCDR, using grader VCDR values. (3) Results: Graders delineated outlines of the cup contour and disc boundaries twice in each of 1815 stereo disc images. For both cases and controls, the mean CDR was highest at the horizontal bisector, particularly in the temporal region, as compared to other degree locations. There was a good correlation between grader CDR at the vertical bisector and clinical VCDR (Spearman Correlation OD: r = 0.78 [95% CI: 0.76-0.79]). An SNP in the

Indexed as

Polymorphism, Single NucleotideAdultBlack or African AmericanCase-Control StudiesDiagnostic Techniques, OphthalmologicalFemaleGlaucoma, Open-AngleHumansMaleMass ScreeningMembrane ProteinsOptic DiskOptic NerveVisual FieldsMembrane ProteinsMPDZ protein, humanAfrican Americanscup-to-disc ratiogenetic associations with cup-to-disc ratioglaucomaoptic nervestereo disc images

Identifiers

PMID34946910
PMCPMC8701339
OpenAlexW4200528505

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.