Evidence map›Paper›PMID 34946903›Full record

ArticleGenes2021

The

Ove Almkvist, Caroline Graff

Open access · goldAbstract readComparative Study
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Suppressing APOE4-induced neural pathologies by targeting the VHL-HIF axis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Stem cell therapy offers new hope for the treatment of Alzheimer's disease.Frontiers in cell and developmental biology · 2025
    Review
  3. Emerging Perspectives on Prime Editor Delivery to the Brain.Pharmaceuticals (Basel, Switzerland) · 2024
    Review
  4. Review
  5. Suppressing APOE4-induced mortality and cellular damage by targeting VHL.bioRxiv : the preprint server for biology · 2024
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Ove AlmkvistDivision of Clinical Geriatrics, Department of Neurobiology Care Sciences and Society, Karolinska Institutet, SE-14157 Stockholm, Sweden.
Caroline GraffTheme Aging, Karolinska University Hospital, SE-14157 Stockholm, Sweden.
Karolinska University Hospital · SEStockholm University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mounting evidence shows that the

Indexed as

MutationAdultAgingAllelesAlzheimer DiseaseAmyloid beta-Protein PrecursorApolipoprotein E4Case-Control StudiesCognitive DysfunctionFemaleHumansMaleMiddle AgedPresenilin-1Amyloid beta-Protein PrecursorApolipoprotein E4APP protein, humanPresenilin-1PSEN1 protein, humanAPOEAPPautosomal-dominant Alzheimer’s diseasecognitionepistasisPSEN1

Identifiers

PMID34946903
PMCPMC8701239
OpenAlexW4200412234

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.