SynthesisGenes2021
The Genetic Landscape of Patent Foramen Ovale: A Systematic Review.
Synthesis in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07349004 (Association Between PFO and Migraine With Aura), which is not on this map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Association Between PFO and Migraine With Aura: A Case-Control Observational Study With Genetic and Neurosonological Analysis
Who cites it
9 citing papers in PubMed.
- The physiology of lived experiences: A hole in the heart and the dive that found it.Experimental physiology · 2026Article
- Long-term incidence and risk factors of atrial fibrillation after percutaneous patent foramen ovale occlusion: a retrospective cohort study.Open heart · 2026Article
- Four novel genetic mutations are associated with patent foramen ovale in Tibetan population using whole exome sequencing.Frontiers in genetics · 2025Article
- A whole-exome sequencing study of patent foramen ovale: investigating genetic variants and their association with cardiovascular disorders.Frontiers in genetics · 2024Article
- Genetic variation in patent foramen ovale: a case-control genome-wide association study.Frontiers in genetics · 2024Article
- Patent Foramen Ovale Percutaneous Closure: Evolution and Ongoing Challenges.Journal of clinical medicine · 2023Review
- Heart-brain axis: Association of congenital heart abnormality and brain diseases.Frontiers in cardiovascular medicine · 2023Review
- Special Issue: "Genomics of Stroke".Genes · 2022Article
- Current Challenges and Future Directions in Handling Stroke Patients With Patent Foramen Ovale-A Brief Review.Frontiers in neurology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patent Foramen Ovale (PFO) is a common postnatal defect of cardiac atrial septation. A certain degree of familial aggregation has been reported. Animal studies suggest the involvement of the Notch pathway and other cardiac transcription factors (GATA4, TBX20, NKX2-5) in Foramen Ovale closure. This review evaluates the contribution of genetic alterations in PFO development. We systematically reviewed studies that assessed rare and common variants in subjects with PFO. The protocol was registered with PROSPERO and followed MOOSE guidelines. We systematically searched English studies reporting rates of variants in PFO subjects until the 30th of June 2021. Among 1231 studies, we included four studies: two of them assessed the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.