Evidence map›Paper›PMID 34946887›Full record

ArticleGenes2021

Examination of Genetic Variants Revealed from a Rat Model of Brain Ischemia in Patients with Ischemic Stroke: A Pilot Study.

Andrey V Khrunin, Gennady V Khvorykh, Alexandra V Rozhkova, Evgeniya A Koltsova, Elizaveta A Petrova, Ekaterina I Kimelfeld, Svetlana A Limborska

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. The Study of the Association of Polymorphisms inInternational journal of molecular sciences · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Andrey V KhruninInstitute of Molecular Genetics of National Research Center "Kurchatov Institute", Kurchatov Sq. 2, 123182 Moscow, Russia.ORCID 0000-0002-7848-4688
Gennady V KhvorykhInstitute of Molecular Genetics of National Research Center "Kurchatov Institute", Kurchatov Sq. 2, 123182 Moscow, Russia.
Alexandra V RozhkovaInstitute of Molecular Genetics of National Research Center "Kurchatov Institute", Kurchatov Sq. 2, 123182 Moscow, Russia.
Evgeniya A KoltsovaDepartment of Neurology, Neurosurgery and Medical Genetics, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Elizaveta A PetrovaDepartment of Neurology, Neurosurgery and Medical Genetics, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Ekaterina I KimelfeldDepartment of Neurology, Neurosurgery and Medical Genetics, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Svetlana A LimborskaInstitute of Molecular Genetics of National Research Center "Kurchatov Institute", Kurchatov Sq. 2, 123182 Moscow, Russia.
Kurchatov Institute · RUPirogov Russian National Research Medical University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although there has been great progress in understanding the genetic bases of ischemic stroke (IS), many of its aspects remain underexplored. These include the genetics of outcomes, as well as problems with the identification of real causative loci and their functional annotations. Therefore, analysis of the results obtained from animal models of brain ischemia could be helpful. We have developed a bioinformatic approach exploring single nucleotide polymorphisms (SNPs) in human orthologues of rat genes expressed differentially under conditions of induced brain ischemia. Using this approach, we identified and analyzed nine SNPs in 553 Russian individuals (331 patients with IS and 222 controls). We explored the association of SNPs with both IS outcomes and with the risk of IS. SNP rs66782529 (

Indexed as

Polymorphism, Single NucleotideAgedAnimalsBrain IschemiaComputational BiologyDisease Models, AnimalFemaleGene FrequencyGenetic Association StudiesHumansMaleMiddle AgedPilot ProjectsRatsStrokeischemic strokeischemic stroke outcomerat model of brain ischemiasingle nucleotide polymorphisms

Identifiers

PMID34946887
PMCPMC8701352
OpenAlexW3216241810

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.