Evidence map›Paper›PMID 34946872›Full record

ArticleGenes2021

Gabriela Rudd Garces, Anna Knebel, Kirsten Hülskötter, Vidhya Jagannathan, Theresa Störk, Marion Hewicker-Trautwein, Tosso Leeb, Holger A Volk

Open access · goldAbstract read
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Multi-organ phenotypes in mice lacking latent TGFβ binding protein 2 (LTBP2).Developmental dynamics : an official publication of the American Association of Anatomists · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Gabriela Rudd GarcesInstitute of Genetics, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland.ORCID 0000-0001-7043-3117
Anna KnebelDepartment of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
Kirsten HülskötterDepartment of Pathology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.ORCID 0000-0003-1577-5856
Vidhya JagannathanInstitute of Genetics, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland.ORCID 0000-0002-8155-0041
Theresa StörkDepartment of Pathology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.ORCID 0000-0002-0395-274X
Marion Hewicker-TrautweinDepartment of Pathology, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
Tosso LeebInstitute of Genetics, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland.ORCID 0000-0003-0553-4880
Holger A VolkDepartment of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.ORCID 0000-0002-7312-638X
University of Veterinary Medicine Hannover, Foundation · DEUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated a highly inbred family of British Shorthair cats in which two offspring were affected by deteriorating paraparesis due to complex skeletal malformations. Radiographs of both affected kittens revealed vertebral deformations with marked stenosis of the vertebral canal from T11 to L3. Additionally, compression of the spinal cord, cerebellar herniation, coprostasis and hypogangliosis were found. The pedigree suggested monogenic autosomal recessive inheritance of the trait. We sequenced the genome of an affected kitten and compared the data to 62 control genomes. This search yielded 55 private protein-changing variants of which only one was located in a likely functional candidate gene,

Indexed as

AnimalsCat DiseasesCatsFemaleFrameshift MutationGenotypeInbreedingLatent TGF-beta Binding ProteinsMaleOsteochondrodysplasiasPedigreePhenotypeRadiographyLatent TGF-beta Binding Proteinsanimal modelbonedevelopmentFelis catusprecision medicineskeletal dysplasiawhole genome sequence

Identifiers

PMID34946872
PMCPMC8701722
OpenAlexW3214987056

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.