Evidence map›Paper›PMID 34946827›Full record

ArticleGenes2021

Next Generation Sequencing Identifies the HLA-DQA1*03:03 Allele in the Type 1 Diabetes Risk-Associated HLA-DQ8 Serotype.

Jürgen Enczmann, Vera Balz, Maximilian Hoffmann, Sebastian Kummer, Christina Reinauer, Carsten Döing, Katharina Förtsch, Alena Welters, Ertan Mayatepek, Thomas Meissner and 2 more

Open access · goldAbstract read
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Jürgen EnczmannInstitute for Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, University Hospital, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.
Vera BalzInstitute for Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, University Hospital, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.
Maximilian HoffmannDepartment of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.
Sebastian KummerDepartment of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.
Christina ReinauerDepartment of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.
Carsten DöingDepartment of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.
Katharina FörtschDepartment of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.
Alena WeltersDepartment of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.
Ertan MayatepekDepartment of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.ORCID 0000-0001-8460-3738
Thomas MeissnerDepartment of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.
Marc JacobsenDepartment of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.
Julia SeyfarthDepartment of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital, Heinrich-Heine-University Duesseldorf, 40225 Duesseldorf, Germany.
Düsseldorf University Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The highest genetic type 1 diabetes risk is conferred by HLA class II haplotypes defined by alleles at the

Indexed as

AdolescentAllelesChildChild, PreschoolDiabetes Mellitus, Type 1FemaleGene FrequencyGenetic Predisposition to DiseaseHaplotypesHigh-Throughput Nucleotide SequencingHLA-DQ alpha-ChainsHLA-DQ AntigensHLA-DRB1 ChainsHumansInfantMaleHLA-DQ8 antigenHLA-DQA1 antigenHLA-DQ alpha-ChainsHLA-DQ AntigensHLA-DRB1 ChainsHLAHLA-DQnext generation sequencingtype 1 diabetestype 1 diabetes risk

Identifiers

PMID34946827
PMCPMC8701008
OpenAlexW3217645212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.