Evidence map›Paper›PMID 34946818›Full record

ArticleGenes2021

Iron Deficiency Caused by Intestinal Iron Loss-Novel Candidate Genes for Severe Anemia.

Carolina Huettmann, Matthias Stelljes, Sugirthan Sivalingam, Manfred Fobker, Alexis Vrachimis, Anne Exler, Christian Wenning, Carola Wempe, Matthias Penke, Andreas Buness and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Carolina HuettmannDepartment of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Muenster, University of Muenster, 48149 Muenster, Germany.
Matthias StelljesMedical Clinic D: Hematology, Haemostaseology, Oncology and Pneumology, University Hospital Muenster, University of Muenster, 48149 Muenster, Germany.
Sugirthan SivalingamCore Unit Bioinformatics Data Analysis, Medical Faculty, University of Bonn, Venusberg-Campus 1, 53127 Bonn, Germany.
Manfred FobkerCenter for Laboratory Medicine, University Hospital Muenster, University of Muenster, 48149 Muenster, Germany.
Alexis VrachimisDepartment of Nuclear Medicine, University Hospital Muenster, University of Muenster, 48149 Muenster, Germany.
Anne ExlerDepartment of Nuclear Medicine, University Hospital Muenster, University of Muenster, 48149 Muenster, Germany.
Christian WenningDepartment of Nuclear Medicine, University Hospital Muenster, University of Muenster, 48149 Muenster, Germany.
Carola WempeDepartment of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Muenster, University of Muenster, 48149 Muenster, Germany.
Matthias PenkeOncological Clinic, St. Franziskus Hospital, Franziskusstraße 6, 49393 Oldenburg, Germany.
Andreas BunessCore Unit Bioinformatics Data Analysis, Medical Faculty, University of Bonn, Venusberg-Campus 1, 53127 Bonn, Germany.
Kerstin U LudwigInstitute of Human Genetics, University Hospital Bonn, Medical Faculty University of Bonn, 53113 Bonn, Germany.ORCID 0000-0002-8541-2519
Martina U MuckenthalerDepartment of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, 69117 Heidelberg, Germany.ORCID 0000-0002-3778-510X
Andrea U SteinbickerDepartment of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Muenster, University of Muenster, 48149 Muenster, Germany.ORCID 0000-0002-5237-961X
University Hospital Münster · DEUniversity of Bonn · DEEuropean Molecular Biology Organization · DEGoethe University Frankfurt · DESt. Franziskus Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The adult human body contains about 4 g of iron. About 1-2 mg of iron is absorbed every day, and in healthy individuals, the same amount is excreted. We describe a patient who presents with severe iron deficiency anemia with hemoglobin levels below 6 g/dL and ferritin levels below 30 ng/mL. Although red blood cell concentrates and intravenous iron have been substituted every month for years, body iron stores remain depleted. Diagnostics have included several esophago-gastro-duodenoscopies, colonoscopies, MRI of the liver, repetitive bone marrow biopsies, psychological analysis, application of radioactive iron to determine intact erythropoiesis, and measurement of iron excretion in urine and feces. Typically, gastrointestinal bleeding is a major cause of iron loss. Surprisingly, intestinal iron excretion in stool in the patient was repetitively increased, without gastrointestinal bleeding. Furthermore, whole exome sequencing was performed in the patient and additional family members to identify potential causative genetic variants that may cause intestinal iron loss. Under different inheritance models, several rare mutations were identified, two of which (in

Indexed as

AgedAged, 80 and overAnemia, Iron-DeficiencyErythropoiesisFemaleGastrointestinal TractGenetic VariationHemorrhageHumansIronIron DeficienciesMaleMiddle AgedMutationIronerythropoiesisgenetically caused iron imbalanceintestinal iron lossironred cells

Identifiers

PMID34946818
PMCPMC8700796
OpenAlexW3217526402

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.