Evidence map›Paper›PMID 34946801›Full record

ArticleGenes2021

SESN3 Inhibited SMAD3 to Relieve Its Suppression for

Weimin Lin, Jindi Zhao, Mengting Yan, Xuexin Li, Kai Yang, Wei Wei, Lifan Zhang, Jie Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Weimin LinCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Jindi ZhaoCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Mengting YanCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Xuexin LiCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Kai YangCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Wei WeiCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Lifan ZhangCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Jie ChenCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Nanjing Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sestrin-3, together with the other two members Sestrin-1 and Sestrin-2, belongs to the Sestrin family. The Sestrin protein family has been demonstrated to be involved in antioxidative, metabolic homeostasis, and even the development of nonalcoholic steatohepatitis (NASH). However, the adipogenic regulatory role of SESN3 in adipogenesis still needs to be further explored. In this study, we demonstrated SESN3 inhibited porcine pre-adipocyte proliferation, thus suppressing its adipogenesis. Meanwhile, SESN3 has been demonstrated to inhibit Smad3 thus protecting against NASH. Further, for our previous study, we found

Indexed as

AdipocytesAdipogenesisAnimalsCell DifferentiationCells, CulturedHeat-Shock ProteinsMiceMicroRNAsNon-alcoholic Fatty Liver DiseaseSestrinsSmad3 ProteinHeat-Shock ProteinsMicroRNAsMirn124 microRNA, mouseSesn3 protein, mouseSestrinsSmad3 ProteinSmad3 protein, mouseadipogenesispigSESN3SMAD3ssc-miR-124-3p

Identifiers

PMID34946801
PMCPMC8701261
OpenAlexW3217615580

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.