Evidence map›Paper›PMID 34946771›Full record

ArticleMolecules (Basel, Switzerland)2021

Stevioside Attenuates Insulin Resistance in Skeletal Muscle by Facilitating IR/IRS-1/Akt/GLUT 4 Signaling Pathways: An In Vivo and In Silico Approach.

Abilasha Deenadayalan, Vijayalakshmi Subramanian, Vijayalakshmi Paramasivan, Vishnu Priya Veeraraghavan, Gayathri Rengasamy, Janaki Coiambatore Sadagopan, Ponnulakshmi Rajagopal, Selvaraj Jayaraman

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Abilasha DeenadayalanDepartment of Anatomy, Saveetha Institute of Medical & Technical Sciences, Chennai 602 105, India.
Vijayalakshmi SubramanianDepartment of Anatomy, Saveetha Institute of Medical & Technical Sciences, Chennai 602 105, India.
Vijayalakshmi ParamasivanDepartment of Pharmacology, Asan Memorial Dental College and Hospitals, Asan Nagar, Chengalpattu, Chennai 602 105, India.
Vishnu Priya VeeraraghavanDepartment of Biochemistry, Saveetha Dental College & Hospital, Saveetha Institute of Medical & Technical Sciences, Chennai 600 077, India.
Gayathri RengasamyDepartment of Biochemistry, Saveetha Dental College & Hospital, Saveetha Institute of Medical & Technical Sciences, Chennai 600 077, India.
Janaki Coiambatore SadagopanDepartment of Anatomy, Bhaarat Medical College, Selaiyur, Chennai 600 073, India.
Ponnulakshmi RajagopalDepartment of Central Research Laboratory, Meenakshi Ammal Dental College and Hospitals, Chennai 600 095, India.
Selvaraj JayaramanDepartment of Biochemistry, Saveetha Dental College & Hospital, Saveetha Institute of Medical & Technical Sciences, Chennai 600 077, India.
Saveetha University · INMeenakshi Ammal Dental College and Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type-2 diabetes mellitus (T2DM), the leading global health burden of this century majorly develops due to obesity and hyperglycemia-induced oxidative stress in skeletal muscles. Hence, developing novel drugs that ameliorate these pathological events is an immediate priority. The study was designed to analyze the possible role of Stevioside, a characteristic sugar from leaves of

Indexed as

Insulin ResistanceAnimalsDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Diterpenes, KauraneGlucose Transporter Type 4GlucosidesInsulin Receptor Substrate ProteinsMaleMuscle, SkeletalProto-Oncogene Proteins c-aktRatsRats, WistarReceptor, InsulinSignal TransductionDiterpenes, KauraneGlucose Transporter Type 4GlucosidesInsulin Receptor Substrate ProteinsIrs1 protein, ratProto-Oncogene Proteins c-aktReceptor, InsulinSlc2a4 protein, ratsteviosideantioxidantsgastrocnemius muscleinsulin resistanceinsulin signalingoxidative stressSteviosidetype-2 diabetes

Identifiers

PMID34946771
PMCPMC8707280
OpenAlexW4200165057

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.