Evidence map›Paper›PMID 34946727›Full record

ArticleMolecules (Basel, Switzerland)2021

Synthesis and Biological Evaluation of S-, O- and Se-Containing Dispirooxindoles.

Maksim Kukushkin, Vladimir Novotortsev, Vadim Filatov, Yan Ivanenkov, Dmitry Skvortsov, Mark Veselov, Radik Shafikov, Anna Moiseeva, Nikolay Zyk, Alexander Majouga and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Women in Bioorganic Chemistry.Molecules (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Maksim KukushkinDepartment of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1/3, GSP-1, 119991 Moscow, Russia.
Vladimir NovotortsevDepartment of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1/3, GSP-1, 119991 Moscow, Russia.
Vadim FilatovDepartment of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1/3, GSP-1, 119991 Moscow, Russia.
Yan IvanenkovLaboratory of Medicinal Chemistry and Bioinformatic, Moscow Institute of Physics and Technology (MIPT), Institutski Pereulok 9, 141701 Dolgoprudny, Russia.
Dmitry SkvortsovDepartment of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1/3, GSP-1, 119991 Moscow, Russia.
Mark VeselovLaboratory of Medicinal Chemistry and Bioinformatic, Moscow Institute of Physics and Technology (MIPT), Institutski Pereulok 9, 141701 Dolgoprudny, Russia.ORCID 0000-0002-8618-0940
Radik ShafikovDepartment of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1/3, GSP-1, 119991 Moscow, Russia.
Anna MoiseevaDepartment of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1/3, GSP-1, 119991 Moscow, Russia.
Nikolay ZykDepartment of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1/3, GSP-1, 119991 Moscow, Russia.
Alexander MajougaDepartment of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1/3, GSP-1, 119991 Moscow, Russia.
Elena BeloglazkinaDepartment of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1/3, GSP-1, 119991 Moscow, Russia.

Funding

Russian Foundation for Basic Research 18-29-08060Russian Foundation for Basic Research 19-03-00201Russian Science Foundation 21-13-00023
6 · The paper itself

Abstract

A series of novel S-, O- and Se-containing dispirooxindole derivatives has been synthesized using 1,3-dipolar cycloaddition reaction of azomethine ylide generated from isatines and sarcosine at the double C=C bond of 5-indolidene-2-chalcogen-imidazolones (chalcogen was oxygen, sulfur or selenium). The cytotoxicity of these dispiro derivatives was evaluated in vitro using different tumor cell lines. Several molecules have demonstrated a considerable cytotoxicity against the panel and showed good selectivity towards colorectal carcinoma HCT116 p53

Indexed as

Antineoplastic AgentsIndolesA549 CellsColorectal NeoplasmsComputer SimulationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHCT116 CellsHEK293 CellsHumansMaleMCF-7 CellsProstatic NeoplasmsProto-Oncogene Proteins c-mdm2Tumor Suppressor Protein p53Antineoplastic AgentsIndolesMDM2 protein, humanProto-Oncogene Proteins c-mdm2TP53 protein, humanTumor Suppressor Protein p533D molecular dockinganticancer activitycytotoxicitydispirooxindolesp53/MDM2 interaction

Identifiers

PMID34946727
PMCPMC8703884

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.