Evidence map›Paper›PMID 34946717›Full record

ArticleMolecules (Basel, Switzerland)2021

Anti-Pathogenic Properties of the Combination of a T3SS Inhibitory Halogenated Pyrrolidone with C-30 Furanone.

Nelly Araceli Aburto-Rodríguez, Naybi Muñoz-Cázares, Víctor Alberto Castro-Torres, Bertha González-Pedrajo, Miguel Díaz-Guerrero, Rodolfo García-Contreras, Héctor Quezada, Israel Castillo-Juárez, Mariano Martínez-Vázquez

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Frontiers in molecular biosciences · 2023
    Article
  5. Review
  6. Review
  7. Using Structure-guided Fragment-Based Drug Discovery to TargetFrontiers in molecular biosciences · 2022
    Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nelly Araceli Aburto-RodríguezDepartamento de Productos Naturales, Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, Ciudad de Mexico 04510, Mexico.
Naybi Muñoz-CázaresLaboratorio de Fitoquímica, Posgrado de Botánica, Colegio de Postgraduados, Texcoco 56230, Mexico.
Víctor Alberto Castro-TorresDepartamento de Productos Naturales, Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, Ciudad de Mexico 04510, Mexico.
Bertha González-PedrajoDepartamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de Mexico 04510, Mexico.ORCID 0000-0002-2125-2157
Miguel Díaz-GuerreroDepartamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de Mexico 04510, Mexico.
Rodolfo García-ContrerasDepartamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, Ciudad de Mexico 04510, Mexico.ORCID 0000-0001-8475-2282
Héctor QuezadaLaboratorio de Investigación en Inmunología y Proteómica, Hospital Infantil de México Federico Gómez, Ciudad de Mexico 06720, Mexico.
Israel Castillo-JuárezLaboratorio de Fitoquímica, Posgrado de Botánica, Colegio de Postgraduados, Texcoco 56230, Mexico.ORCID 0000-0001-6983-5565
Mariano Martínez-VázquezDepartamento de Productos Naturales, Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, Ciudad de Mexico 04510, Mexico.ORCID 0000-0003-0954-2765

Funding

UNAM PAPITT IN211819
6 · The paper itself

Abstract

Antimicrobial resistance is one of the current public health challenges to be solved. The World Health Organization (WHO) has urgently called for the development of strategies to expand the increasingly limited antimicrobial arsenal. The development of anti-virulence therapies is a viable option to counteract bacterial infections with the possibility of reducing the generation of resistance. Here we report on the chemical structures of pyrrolidones DEXT 1-4 (previously identified as furan derivatives) and their anti-virulence activity on

Indexed as

Anti-Bacterial AgentsFuransHydrocarbons, HalogenatedPseudomonas aeruginosaPseudomonas InfectionsPyrrolidinonesAnimalsHumansMiceNecrosisQuorum SensingType III Secretion SystemsVirulence FactorsAnti-Bacterial Agentsfuranone C-30FuransHydrocarbons, HalogenatedPyrrolidinonesType III Secretion SystemsVirulence Factorsanti-virulenceanti-virulence combination therapiespyrrolidonequorum sensingtype III secretion system

Identifiers

PMID34946717
PMCPMC8707098

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.