Evidence map›Paper›PMID 34946704›Full record

ReviewMolecules (Basel, Switzerland)2021

Recent Advancements in the Development of Anti-Breast Cancer Synthetic Small Molecules.

Eslam B Elkaeed, Hayam A Abd El Salam, Ahmed Sabt, Ghada H Al-Ansary, Wagdy M Eldehna

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Selected Thieno[2,3-Molecules (Basel, Switzerland) · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. 2-{5-[(International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Eslam B ElkaeedDepartment of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Ad Diriyah, Riyadh 13713, Saudi Arabia.ORCID 0000-0002-2546-8035
Hayam A Abd El SalamDepartment of Green Chemistry, National Research Center, Dokki, Cairo 12622, Egypt.
Ahmed SabtChemistry of Natural Compounds Department, National Research Center, Dokki, Cairo 12622, Egypt.ORCID 0000-0001-6976-0196
Ghada H Al-AnsaryDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt.
Wagdy M EldehnaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh 33516, Egypt.ORCID 0000-0001-6996-4017

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Among all cancer types, breast cancer (BC) still stands as one of the most serious diseases responsible for a large number of cancer-associated deaths among women worldwide, and diagnosed cases are increasing year by year worldwide. For a very long time, hormonal therapy, surgery, chemotherapy, and radiotherapy were used for breast cancer treatment. However, these treatment approaches are becoming progressively futile because of multidrug resistance and serious side effects. Consequently, there is a pressing demand to develop more efficient and safer agents that can fight breast cancer belligerence and inhibit cancer cell proliferation, invasion and metastasis. Currently, there is an avalanche of newly designed and synthesized molecular entities targeting multiple types of breast cancer. This review highlights several important synthesized compounds with promising anti-BC activity that are categorized according to their chemical structures.

Indexed as

Antineoplastic AgentsBreast NeoplasmsCell ProliferationDrug Screening Assays, AntitumorFemaleHumansMCF-7 CellsAntineoplastic Agentsbreast cancer therapychemical scaffoldhuman malignanciesmechanistic insightsorganic synthesis

Identifiers

PMID34946704
PMCPMC8709016

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.