Evidence map›Paper›PMID 34946697›Full record

ArticleMolecules (Basel, Switzerland)2021

Discovery of Octahydroisoindolone as a Scaffold for the Selective Inhibition of Chitinase B1 from

Alberto Marbán-González, Armando Hernández-Mendoza, Mario Ordóñez, Rodrigo Said Razo-Hernández, José Luis Viveros-Ceballos

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Alberto Marbán-GonzálezCentro de Investigaciones Químicas, Instituto de Investigación en Ciencias Básicas y Aplicadas, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Cuernavaca 62209, Mexico.
Armando Hernández-MendozaCentro de Investigación en Dinámica Celular, Instituto de Investigación en Ciencias Básicas y Aplicadas, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Cuernavaca 62209, Mexico.ORCID 0000-0002-7809-6888
Mario OrdóñezCentro de Investigaciones Químicas, Instituto de Investigación en Ciencias Básicas y Aplicadas, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Cuernavaca 62209, Mexico.ORCID 0000-0001-9395-7079
Rodrigo Said Razo-HernándezCentro de Investigación en Dinámica Celular, Instituto de Investigación en Ciencias Básicas y Aplicadas, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Cuernavaca 62209, Mexico.ORCID 0000-0002-9716-9376
José Luis Viveros-CeballosCentro de Investigaciones Químicas, Instituto de Investigación en Ciencias Básicas y Aplicadas, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Cuernavaca 62209, Mexico.ORCID 0000-0003-0202-4180
Universidad Autónoma del Estado de Morelos · MX

Funding

Consejo Nacional de Ciencia y Tecnología 256985, 286614, 706529
6 · The paper itself

Abstract

Chitinases represent an alternative therapeutic target for opportunistic invasive mycosis since they are necessary for fungal cell wall remodeling. This study presents the design of new chitinase inhibitors from a known hydrolysis intermediate. Firstly, a bioinformatic analysis of

Indexed as

ChitinasesFungal ProteinsMolecular Docking SimulationAntifungal AgentsAspergillus fumigatusEnzyme InhibitorsHexosaminidasesAntifungal AgentsChitinaseschitotriosidaseEnzyme InhibitorsFungal ProteinsHexosaminidasesbioinformatic analysischitinase AfChiB1molecular dockingmolecular similarityoxazolinium ion

Identifiers

PMID34946697
PMCPMC8705689
OpenAlexW4200571550

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.