Evidence map›Paper›PMID 34946686›Full record

ArticleMolecules (Basel, Switzerland)2021

AaTs-1: A Tetrapeptide from

Dorra Aissaoui-Zid, Mohamed-Chiheb Saada, Wassim Moslah, Marie Potier-Cartereau, Aude Lemettre, Houcemeddine Othman, Marc Gaysinski, Zaineb Abdelkafi-Koubaa, Soumaya Souid, Naziha Marrakchi and 3 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

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  12. F2 peptide fraction ofAvicenna journal of phytomedicine
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 4 countries.

Dorra Aissaoui-ZidLaboratory of Biomolecules, Venoms and Theranostic Applications, LR20IPT01, Institut Pasteur of Tunis, University of Tunis El Manar, Tunis 1002, Tunisia.ORCID 0000-0001-8049-8950
Mohamed-Chiheb SaadaLaboratory of Biomolecules, Venoms and Theranostic Applications, LR20IPT01, Institut Pasteur of Tunis, University of Tunis El Manar, Tunis 1002, Tunisia.
Wassim MoslahLaboratory of Biomolecules, Venoms and Theranostic Applications, LR20IPT01, Institut Pasteur of Tunis, University of Tunis El Manar, Tunis 1002, Tunisia.
Marie Potier-CartereauN2C UMR 1069, INSERM, University of Tours, 37032 Tours, France.
Aude LemettreN2C UMR 1069, INSERM, University of Tours, 37032 Tours, France.
Houcemeddine OthmanLaboratory of Biomolecules, Venoms and Theranostic Applications, LR20IPT01, Institut Pasteur of Tunis, University of Tunis El Manar, Tunis 1002, Tunisia.
Marc GaysinskiChemistry Technological Platform NMR Department, Faculty of Sciences, University of Nice Sophia Antipolis, Parc Valrose, 06108 Nice, France.
Zaineb Abdelkafi-KoubaaLaboratory of Biomolecules, Venoms and Theranostic Applications, LR20IPT01, Institut Pasteur of Tunis, University of Tunis El Manar, Tunis 1002, Tunisia.
Soumaya SouidLaboratory of Molecular Epidemiology and Experimental Pathology Applied to Infectious Diseases, LR16IPT04, Institut Pasteur of Tunis, University of Tunis El Manar, Tunis 1002, Tunisia.
Naziha MarrakchiLaboratory of Biomolecules, Venoms and Theranostic Applications, LR20IPT01, Institut Pasteur of Tunis, University of Tunis El Manar, Tunis 1002, Tunisia.
Christophe VandierN2C UMR 1069, INSERM, University of Tours, 37032 Tours, France.
Khadija Essafi-BenkhadirLaboratory of Molecular Epidemiology and Experimental Pathology Applied to Infectious Diseases, LR16IPT04, Institut Pasteur of Tunis, University of Tunis El Manar, Tunis 1002, Tunisia.ORCID 0000-0003-1371-1963
Najet Srairi-AbidLaboratory of Biomolecules, Venoms and Theranostic Applications, LR20IPT01, Institut Pasteur of Tunis, University of Tunis El Manar, Tunis 1002, Tunisia.
Tunis University · TNUniversité de Tours · FRUniversité Côte d'Azur · FR

Funding

research grant Partenariat Hubert Curien-Utique (PHC-Utique) [code 17G 0811].Tunisian Ministry of Higher Education and Scientific Research (LR11IPT08)
6 · The paper itself

Abstract

Glioblastoma is an aggressive cancer, against which medical professionals are still quite helpless, due to its resistance to current treatments. Scorpion toxins have been proposed as a promising alternative for the development of effective targeted glioblastoma therapy and diagnostic. However, the exploitation of the long peptides could present disadvantages. In this work, we identified and synthetized AaTs-1, the first tetrapeptide from

Indexed as

GlioblastomaAnimalsAntineoplastic AgentsCell ProliferationGene Expression Regulation, NeoplasticHumansOligopeptidesReceptors, Formyl PeptideReceptors, LipoxinScorpionsScorpion VenomsTumor Suppressor Protein p53Up-RegulationAntineoplastic AgentsFPR2 protein, humanOligopeptidesReceptors, Formyl PeptideReceptors, LipoxinScorpion VenomsTP53 protein, humanTumor Suppressor Protein p53AaTs-1antagonistantiproliferative effectFPRL-1 receptorglioblastomascorpion venom

Identifiers

PMID34946686
PMCPMC8704564
OpenAlexW4200567968

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.