ArticleMolecules (Basel, Switzerland)2021
Hydrolytic Degradation of Polylactic Acid Fibers as a Function of pH and Exposure Time.
Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The trial behind it
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Who cites it
33 citing papers in PubMed.
- Upcycling of Commercial Biobased Polyester BioplasticsTurning Used or Spoiled Materials into Added-Value Products.ACS polymers Au · 2026Review
- A Green Approach Towards Desalination: Sustainable Poly(lactic acid) Membranes for Pervaporation Desalination.Membranes · 2026Review
- Solvent Evaporation-Controlled Stereocomplexation in PLLA/PDLA Films for Sustainable Packaging.Polymers · 2026Article
- Design and Characterization of 3D Printed Auxetic PLA-HA Composite Scaffolds for Biomedical Application.Materials (Basel, Switzerland) · 2026Article
- Abiotic Hydrolysis of Microplastics: Influence of Polymer Chain Scission on Particle Fragmentation and Dissolved Organic Carbon Release.Environmental science & technology · 2026Article
- Polymer-Grafted WSACS nano · 2026Article
- Application of PLCL as a biodegradable polymer in biomedical engineering.Journal of materials science. Materials in medicine · 2026Review
- Highly Efficient Biodegradation of Postconsumer Polylactic Acid Waste: The First Report onInternational journal of microbiology · 2026Article
- 3D-Printed Multifunctional Multicompartment Polymer-Based Capsules for Tunable and Spatially Controlled Drug Release.Journal of functional biomaterials · 2025Article
- Impact of Polymer Degradation on Cellular Behavior in Tissue Engineering.Bioprinting (Amsterdam, Netherlands) · 2025Article
- Bone Regeneration in Rat Calvaria Using 3D-Printed Scaffolds with Graded Porosity and In Vitro Degradation.ACS omega · 2025Article
- Coaxial Electrospray of Nanodrug-Loaded Porous Polylactic Acid/Poly(Ethylene Oxide) Core-Shell Microparticles for Intrapulmonary Drug Delivery.Journal of biomedical materials research. Part A · 2025Article
- Biodegradable Polyesters: Approaches to Increase Degradation Rates for Biomedical Applications.ACS macro letters · 2025Review
- Accelerated Hydrolytic Degradation of PLA/Magnesium Composite Films: Material Properties and Stem Cell Interaction.Polymers · 2025Article
- A Review of Polylactic Acid (PLA) and Poly(3-hydroxybutyrate) (PHB) as Bio-Sourced Polymers for Membrane Production Applications.Membranes · 2025Review
- Design and performance verification of a novel vascular anastomosis connector.Scientific reports · 2025Article
- Development of a biodegradable α-TCP/PLA/nMgO composite for enhanced guided bone regeneration.Scientific reports · 2025Article
- Effect of the Interior Fill Percentage on the Deterioration of the Mechanical Properties of FFF-3D-Printed PLA Structures.Polymers · 2025Article
- Electrically Active Biomaterials for Stimulation and Regeneration in Tissue Engineering.Journal of biomedical materials research. Part A · 2025Review
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Polylactic acid (PLA) is a widely used bioresorbable polymer in medical devices owing to its biocompatibility, bioresorbability, and biodegradability. It is also considered a sustainable solution for a wide variety of other applications, including packaging. Because of its widespread use, there have been many studies evaluating this polymer. However, gaps still exist in our understanding of the hydrolytic degradation in extreme pH environments and its impact on physical and mechanical properties, especially in fibrous materials. The goal of this work is to explore the hydrolytic degradation of PLA fibers as a function of a wide range of pH values and exposure times. To complement the experimental measurements, molecular-level details were obtained using both molecular dynamics (MD) simulations with ReaxFF and density functional theory (DFT) calculations. The hydrolytic degradation of PLA fibers from both experiments and simulations was observed to have a faster rate of degradation in alkaline conditions, with 40% of strength loss of the fibers in just 25 days together with an increase in the percent crystallinity of the degraded samples. Additionally, surface erosion was observed in these PLA fibers, especially in extreme alkaline environments, in contrast to bulk erosion observed in molded PLA grafts and other materials, which is attributed to the increased crystallinity induced during the fiber spinning process. These results indicate that spun PLA fibers function in a predictable manner as a bioresorbable medical device when totally degraded at end-of-life in more alkaline conditions.
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Registered trials
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