Evidence map›Paper›PMID 34946628›Full record

ArticleMolecules (Basel, Switzerland)2021

Janerin Induces Cell Cycle Arrest at the G2/M Phase and Promotes Apoptosis Involving the MAPK Pathway in THP-1, Leukemic Cell Line.

Mohammad Z Ahmed, Fahd A Nasr, Wajhul Qamar, Omar M Noman, Javed Masood Khan, Abdullah A Al-Mishari, Ali S Alqahtani

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Pharmacological and Phytochemical Insights IntoFood science & nutrition · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mohammad Z AhmedDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Fahd A NasrDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-6496-7822
Wajhul QamarDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Omar M NomanDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0003-0902-6381
Javed Masood KhanDepartment of Food Science and Nutrition, College of Food and Agricultural Sciences, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0003-0567-5712
Abdullah A Al-MishariDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0001-5002-2337
Ali S AlqahtaniDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-1034-7441

Funding

King Saud University RSP-2021/132
6 · The paper itself

Abstract

Janerin is a cytotoxic sesquiterpene lactone that has been isolated and characterized from different species of the

Indexed as

Antineoplastic Agents, PhytogenicLeukemiaSesquiterpenesApoptosisG2 Phase Cell Cycle CheckpointsHumansMAP Kinase Signaling SystemM Phase Cell Cycle CheckpointsTHP-1 CellsAntineoplastic Agents, PhytogenicSesquiterpenesBax/Bcl-2caspaseCentaurothamnus maximusjanerin

Identifiers

PMID34946628
PMCPMC8705386

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.