Evidence map›Paper›PMID 34946573›Full record

ArticleMolecules (Basel, Switzerland)2021

Monoterpene-Containing Substituted Coumarins as Inhibitors of Respiratory Syncytial Virus (RSV) Replication.

Tatyana M Khomenko, Anna A Shtro, Anastasia V Galochkina, Yulia V Nikolaeva, Galina D Petukhova, Sophia S Borisevich, Dina V Korchagina, Konstantin P Volcho, Nariman F Salakhutdinov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Tatyana M KhomenkoDepartment of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Acad. Lavrentjev Ave. 9, 630090 Novosibirsk, Russia.
Anna A ShtroLaboratory of Chemotherapy for Viral Infections, Smorodintsev Research Intitute of Influenza, Professor Popova Str., 15/17, 197376 St. Petersburg, Russia.
Anastasia V GalochkinaLaboratory of Chemotherapy for Viral Infections, Smorodintsev Research Intitute of Influenza, Professor Popova Str., 15/17, 197376 St. Petersburg, Russia.
Yulia V NikolaevaLaboratory of Chemotherapy for Viral Infections, Smorodintsev Research Intitute of Influenza, Professor Popova Str., 15/17, 197376 St. Petersburg, Russia.
Galina D PetukhovaLaboratory of Chemotherapy for Viral Infections, Smorodintsev Research Intitute of Influenza, Professor Popova Str., 15/17, 197376 St. Petersburg, Russia.
Sophia S BorisevichLaboratory of Physical Chemistry, Ufa Chemistry Institute of the Ufa Federal Research Center, 71 Octyabrya pr., 450054 Ufa, Russia.ORCID 0000-0001-8481-0470
Dina V KorchaginaDepartment of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Acad. Lavrentjev Ave. 9, 630090 Novosibirsk, Russia.
Konstantin P VolchoDepartment of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Acad. Lavrentjev Ave. 9, 630090 Novosibirsk, Russia.ORCID 0000-0002-4083-9324
Nariman F SalakhutdinovDepartment of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Acad. Lavrentjev Ave. 9, 630090 Novosibirsk, Russia.
Novosibirsk Institute of Organic Chemistry · RUResearch Institute of Influenza · RUUfa Institute of Chemistry · RU

Funding

Russian Science Foundation 21-13-00026
6 · The paper itself

Abstract

Respiratory syncytial virus (RSV) is a critical cause of infant mortality. However, there are no vaccines and adequate drugs for its treatment. We showed, for the first time, that O-linked coumarin-monoterpene conjugates are effective RSV inhibitors. The most potent compounds are active against both RSV serotypes, A and B. According to the results of the time-of-addition experiment, the conjugates act at the early stages of virus cycle. Based on molecular modelling data, RSV F protein may be considered as a possible target.

Indexed as

Antiviral AgentsCoumarinsMicrobial Sensitivity TestsModels, MolecularMolecular StructureMonoterpenesRespiratory Syncytial Virus, HumanVirus ReplicationAntiviral AgentsCoumarinsMonoterpenesantiviral activitycoumarincytotoxicityF proteinmolecular modellingrespiratory syncytial virusterpene

Identifiers

PMID34946573
PMCPMC8708370
OpenAlexW4200158185

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.