Evidence map›Paper›PMID 34946540›Full record

ArticleMolecules (Basel, Switzerland)2021

Molecular Docking and Dynamics Investigations for Identifying Potential Inhibitors of the 3-Chymotrypsin-like Protease of SARS-CoV-2: Repurposing of Approved Pyrimidonic Pharmaceuticals for COVID-19 Treatment.

Amin Osman Elzupir

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Inhibitory Activity ofPlants (Basel, Switzerland) · 2023
    Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Amin Osman ElzupirCollege of Science, Deanship of Scientific Research, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia.
Imam Mohammad ibn Saud Islamic University · SA

Funding

Deanship of Scientific Research, Imam Mohammad Ibn Saud Islamic University (IMSIU) 21-13-18-040
6 · The paper itself

Abstract

This study demonstrates the inhibitory effect of 42 pyrimidonic pharmaceuticals (PPs) on the 3-chymotrypsin-like protease of SARS-CoV-2 (3CL

Indexed as

COVID-19 Drug TreatmentAcetatesAntiviral AgentsCoronavirus 3C ProteasesCoronavirus Papain-Like ProteasesCytidine Diphosphate CholineDrug Evaluation, PreclinicalDrug RepositioningHumansMolecular Docking SimulationMolecular Dynamics SimulationProtease InhibitorsSARS-CoV-2UridineAcetatesAntiviral AgentsCoronavirus 3C ProteasesCoronavirus Papain-Like ProteasesCytidine Diphosphate Cholinepapain-like protease, SARS-CoV-2Protease InhibitorsUridineuridine triacetate3-chymotrypsin-like proteasebinding free energycoronavirus SARS-CoV-2COVID-19molecular dynamics simulationspyrimidonic pharmaceuticals

Identifiers

PMID34946540
PMCPMC8707611
OpenAlexW4200321955

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.