Evidence map›Paper›PMID 34946356›Full record

ArticleHealthcare (Basel, Switzerland)2021

Drug Induced Liver Injury: Perspective of the Adverse Drug Reaction Reports to the Portuguese Pharmacovigilance System from 2010 to 2019.

David Ricardo da Conceição Marçal Alves Nunes, Michèle Claire Breton, Cristina Sofia de Jesus Monteiro, Jorge Luiz Dos Santos

Open access · goldAbstract read
In one paragraph

Article in Healthcare (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

David Ricardo da Conceição Marçal Alves NunesFaculdade de Ciências da Saúde, Universidade da Beira Interior, 6200-506 Covilhã, Portugal.ORCID 0000-0001-9917-2109
Michèle Claire BretonCICS-UBI-Health Sciences Research Centre, Faculdade de Ciências da Saúde, Universidade da Beira Interior, 6200-506 Covilhã, Portugal.
Cristina Sofia de Jesus MonteiroFaculdade de Ciências da Saúde, Universidade da Beira Interior, 6200-506 Covilhã, Portugal.ORCID 0000-0002-5225-6222
Jorge Luiz Dos SantosFaculdade de Ciências da Saúde, Universidade da Beira Interior, 6200-506 Covilhã, Portugal.ORCID 0000-0002-3839-0222
University of Beira Interior · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDrug induced liver injury (DILI) is an adverse drug reaction that causes liver damage in a predictable (dose-dependent) or an unpredictable (idiosyncratic) fashion. We performed an assessment of DILI in Portugal, by analyzing the reports, sent to the Portuguese Pharmacovigilance System (PPS).

methodsA search was performed on the PPS database, in a 10-year time frame, from 1 January 2010 to 31 December 2019.

resultsThere was not a prevalence of either sex in any age group. Most reports (

conclusionsDILI is rare but can be fatal. As such, an active search of DILI is necessary.

Indexed as

adverse drug reaction reporting systemsdrug induced liver diseasespharmacovigilance systempost-marketingproduct surveillance

Identifiers

PMID34946356
PMCPMC8702164
OpenAlexW3214764229

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.