Evidence map›Paper›PMID 34946347›Full record

ArticleHealthcare (Basel, Switzerland)2021

Factors That Influence Mortality in Critically Ill Patients with SARS-CoV-2 Infection: A Multicenter Study in the Kingdom of Saudi Arabia.

Khalid A Alhasan, Mohamed A Shalaby, Mohamad-Hani Temsah, Fadi Aljamaan, Reem Shagal, Talal AlFaadhel, Mohammed Alomi, Khalid AlMatham, Adi J AlHerbish, Rupesh Raina and 10 more

Abstract read
In one paragraph

Article in Healthcare (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Khalid A AlhasanPediatrics Department, College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-4291-8536
Mohamed A ShalabyPediatric Nephrology Center of Excellence, Department of Pediatrics, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Mohamad-Hani TemsahPediatrics Department, College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-4389-9322
Fadi AljamaanCritical Care Department, College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia.
Reem ShagalPediatrics Department, College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia.
Talal AlFaadhelDepartment of Medicine, College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia.
Mohammed AlomiPrince Mohammed bin Abdulaziz Hospital, King Salman Center for Kidney Diseases, Ministry of Health, Riyadh 14214, Saudi Arabia.
Khalid AlMathamKing Fahad Medical City, Ministry of Health, Riyadh 11525, Saudi Arabia.
Adi J AlHerbishPediatrics Department, College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia.
Rupesh RainaPediatrics Nephrology, Akron Children's Hospital, Akron, OH 44241, USA.
Sidharth K SethiPediatric Nephrology, Medanta, The Medicity, Gurgaon 122001, India.
Sarah AlsubaiePediatrics Department, College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-3128-5921
Marwah H HakamiPediatric Department, East Jeddah General Hospital, Jeddah 636012, Saudi Arabia.
Najla M AlharbiPediatric Department, East Jeddah General Hospital, Jeddah 636012, Saudi Arabia.
Razan A ShebeliPediatric Department, East Jeddah General Hospital, Jeddah 636012, Saudi Arabia.
Hanan Mohamed NurPediatric Department, East Jeddah General Hospital, Jeddah 636012, Saudi Arabia.
Ohoud F KashariPediatric Department, East Jeddah General Hospital, Jeddah 636012, Saudi Arabia.
Faiza A QariDepartment of Medicine, College of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Amr S AlbannaKing Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Jeddah 11481, Saudi Arabia.
Jameela A KariPediatric Nephrology Center of Excellence, Department of Pediatrics, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSARS-CoV-2 infection has a high mortality rate and continues to be a global threat, which warrants the identification of all mortality risk factors in critically ill patients.

methodsThis is a retrospective multicenter cohort study conducted in five hospitals in the Kingdom of Saudi Arabia (KSA). We enrolled patients with confirmed SARS-COV-2 infection admitted to any of the intensive care units from the five hospitals between March 2020 and July 2020, corresponding to the peak of recorded COVID-19 cases in the KSA.

resultsIn total, 229 critically ill patients with confirmed SARS-CoV-2 infection were included in the study. The presenting symptoms and signs of patients who died during hospitalization were not significantly different from those observed among patients who survived. The baseline comorbidities that were significantly associated with in-hospital mortality were diabetes (62% vs. 48% among patients who died and survived (

conclusionIn our cohort, the baseline comorbidities that were significantly associated with in-hospital mortality were diabetes, underlying cardiac disease, and underlying kidney disease. Additionally, the factors that independently influenced mortality among critically ill COVID-19 patients were high Activated Partial Thromboplastin Time (aPTT )and international normalization ratio (INR), acidosis, and high ferritin.

Indexed as

COVID-19 diseaseoutcomesrisk of mortalitySARS-CoV-2 infectionSaudi Arabia

Identifiers

PMID34946347
PMCPMC8701249

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.