Evidence map›Paper›PMID 34946197›Full record

ArticleMicroorganisms2021

Incidence of Histoplasmosis in a Cohort of People with HIV: From Estimations to Reality.

Narda Medina, Juan Luis Rodriguez-Tudela, Luis Aguirre, Luis R Salazar, Osmar Gamboa, Oscar Bonilla, Juan C Pérez, Eduardo Arathoon, David W Denning, Ana Alastruey-Izquierdo

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 4 countries.

Narda MedinaAsociación de Salud Integral, Guatemala City 01001, Guatemala.ORCID 0000-0001-6176-0052
Juan Luis Rodriguez-TudelaGlobal Action Fund for Fungal Infections, 01564 Geneva, Switzerland.
Luis AguirreAsociación de Salud Integral, Guatemala City 01001, Guatemala.
Luis R SalazarAsociación de Salud Integral, Guatemala City 01001, Guatemala.ORCID 0000-0001-7836-4136
Osmar GamboaAsociación de Salud Integral, Guatemala City 01001, Guatemala.ORCID 0000-0001-7409-1388
Oscar BonillaClínica Familiar "Luis Ángel García", Hospital General San Juan de Dios, Guatemala City 01001, Guatemala.ORCID 0000-0003-4227-3632
Juan C PérezClínica Familiar "Luis Ángel García", Hospital General San Juan de Dios, Guatemala City 01001, Guatemala.
Eduardo ArathoonAsociación de Salud Integral, Guatemala City 01001, Guatemala.ORCID 0000-0002-6225-7413
David W DenningGlobal Action Fund for Fungal Infections, 01564 Geneva, Switzerland.ORCID 0000-0001-5626-2251
Ana Alastruey-IzquierdoGlobal Action Fund for Fungal Infections, 01564 Geneva, Switzerland.ORCID 0000-0001-8651-4405
Unidad de Cirugía Cardiovascular de Guatemala · GTGlobal Fund to Fight AIDS, Tuberculosis and Malaria · CHHospital General San Juan de Dios · GT

Funding

JYLAG, GAFFI 001
6 · The paper itself

Abstract

Among people with HIV, histoplasmosis represents an important cause of mortality. Previous studies provided estimates of the disease incidence. Here, we compared those estimates with the results obtained from a screening program implemented in Guatemala, which included histoplasmosis detection for people with HIV. To compare the results of this program with previous estimations, a literature search was performed and reports concerning histoplasmosis incidence were analyzed. The screening program enrolled 6366 patients. The overall histoplasmosis incidence in the screening program was 7.4%, which was almost double that estimated in previous studies. From 2017 to 2019, the screening program showed an upward trend in histoplasmosis cases from 6.5% to 8.8%. Histoplasmosis overall mortality among those who were newly HIV diagnosed showed a decrease at 180 days from 32.8% in 2017 to 21.2% in 2019. The screening approach using rapid diagnostic assays detects histoplasmosis cases more quickly, allowing a specific treatment to be administered, which decreases the mortality of the disease. Therefore, the use of these new techniques, especially in endemic areas of histoplasmosis, must be implemented.

Indexed as

antigenhistoplasmosisHIVopportunistic infections

Identifiers

PMID34946197
PMCPMC8703839
OpenAlexW4225597941

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.