Evidence map›Paper›PMID 34946179›Full record

ReviewMicroorganisms2021

Antiviral Immunity in SARS-CoV-2 Infection: From Protective to Deleterious Responses.

Grigore Mihaescu, Mariana Carmen Chifiriuc, Corneliu Ovidiu Vrancianu, Marian Constantin, Roxana Filip, Mihaela Roxana Popescu, Liliana Burlibasa, Anca Cecilia Nicoara, Alexandra Bolocan, Ciprian Iliescu and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Grigore MihaescuFaculty of Biology, University of Bucharest, 030018 Bucharest, Romania.
Mariana Carmen ChifiriucFaculty of Biology, University of Bucharest, 030018 Bucharest, Romania.ORCID 0000-0001-6098-1857
Corneliu Ovidiu VrancianuFaculty of Biology, University of Bucharest, 030018 Bucharest, Romania.
Marian ConstantinInstitute of Biology, 060031 Bucharest, Romania.
Roxana FilipFaculty of Medicine and Biological Sciences, Stefan cel Mare University of Suceava, 720229 Suceava, Romania.
Mihaela Roxana PopescuDepartment of Cardiology, Elias Emergency University Hospital "Carol Davila", University of Medicine and Pharmacy "Carol Davila", 020021 Bucharest, Romania.ORCID 0000-0002-4539-5259
Liliana BurlibasaFaculty of Biology, University of Bucharest, 030018 Bucharest, Romania.ORCID 0000-0003-0596-9331
Anca Cecilia NicoaraFaculty of Pharmacy, University of Medicine and Pharmacy "Carol Davila", 020021 Bucharest, Romania.
Alexandra BolocanGeneral Surgery, University of Medicine and Pharmacy "Carol Davila", 020021 Bucharest, Romania.ORCID 0000-0001-7042-5248
Ciprian IliescuNational Institute for Research and Development in Microtechnologies-IMT, 077190 Bucharest, Romania.
Gratiela Gradisteanu PircalabioruLife, Environmental and Earth Sciences Division, Research Institute of the University of Bucharest, 050096 Bucharest, Romania.
University of Bucharest · ROCarol Davila University of Medicine and Pharmacy · ROAcademia Oamenilor de Știință din România · ROŞtefan cel Mare University of Suceava · RO

Funding

Unitatea Executiva Pentru Finantarea Invatamantului Superior a Cercetarii Dezvoltarii si Inovarii 13SOLUnitatea Executiva Pentru Finantarea Invatamantului Superior a Cercetarii Dezvoltarii si Inovarii CNFIS-CDI- 2021-0405
6 · The paper itself

Abstract

After two previous episodes, in 2002 and 2012, when two highly pathogenic coronaviruses (SARS, MERS) with a zoonotic origin emerged in humans and caused fatal respiratory illness, we are today experiencing the COVID-19 pandemic produced by SARS-CoV-2. The main question of the year 2021 is if naturally- or artificially-acquired active immunity will be effective against the evolving SARS-CoV-2 variants. This review starts with the presentation of the two compartments of antiviral immunity-humoral and cellular, innate and adaptive-underlining how the involved cellular and molecular actors are intrinsically connected in the development of the immune response in SARS-CoV-2 infection. Then, the SARS-CoV-2 immunopathology, as well as the derived diagnosis and therapeutic approaches, will be discussed.

Indexed as

antibodiesantiviralimmune responseinflammationlymphocytesSARS-CoV-2

Identifiers

PMID34946179
PMCPMC8703918
OpenAlexW4200189389

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.